Project Grant K99AI190055
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is funding research to investigate the mechanisms by which bacterial cholesterol-dependent cytolysins (CDCs) activate the NLRP3 inflammasome, a key innate immune signaling complex responsible for triggering inflammation. The $506,394 award, effective from January 24, 2025 through December 31, 2029, will support studies using...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $489,500 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to The Children's Hospital Corporation (doing business as Boston Children's Hospital) on July 24, 2025. The grant will fund structural studies of the full-length nucleocapsid (N) protein of SARS-CoV-2, the virus that causes COVID-19. The goal is to determine the high-resolution structure of the full-length N protein in complex...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $522,524 to The Children's Hospital Corporation, doing business as Boston Children's Hospital, to conduct research on the mechanism of inflammation in deficiency of adenosine deaminase 2 (DADA2). The research aims to examine the activation of unfolded protein response pathways and cytokine production in...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $394,320 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to research how extracellular matrix (ECM) stiffness regulates the NLRP3 inflammasome in macrophages. The objective is to define the mechanisms by which ECM stiffness controls the NLRP3 inflammasome, which is relevant to...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), is providing $130,932.00 to support research on the molecular mechanisms underlying the activation and regulation of the inflammasome executioner protein gasdermin D (GSDMD). The research aims to elucidate the processes of GSDMD pore formation and membrane rupture, which are critical for the inflammatory...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to uncover the mechanisms by which the innate immune effector TRIM56 restricts a broad range of viruses, with a focus on HIV-1. The $155,804 award to The Children's Hospital Corporation, doing business as Boston Children's Hospital, aims to investigate whether TRIM56 directly binds to viral RNA to...
- This Project Grant award of $578,093.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to elucidate the structure and function of a novel damage-associated molecular pattern (DAMP) receptor, CLEC17A, and its murine homolog CD209f/g, and their common ligand, GAPDH, in human and mouse innate immune systems. The central hypothesis is that these receptors on innate immune cells...
- This $147,656 federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand the role of transmembrane proteins in the cell division process of the malaria parasite Plasmodium falciparum. The award, effective January 22, 2025 through October 31, 2027, will enable the integration of biochemical and super-resolution microscopy approaches to decipher...
- This $501,800 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), to The Children's Hospital Corporation (doing business as Boston Children's Hospital) on August 4, 2025. The grant supports research to use cryo-electron tomography to gain new molecular insights into the divergent cell division process of the Plasmodium falciparum parasite, which causes malaria. The research...
- This $489,500 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research grant program (CFDA 93.855), supports research to overcome technical obstacles in understanding the assembly and regulation of B cell antigen receptors (BCRs). The award aims to develop effective adaptive immunity following infection and vaccination by engineering appropriate cell lines and utilizing native membrane environments to study BCR...
This Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to elucidate the molecular mechanisms underlying the activation and regulation of the NLRP3 inflammasome. The $122,472 award, granted on Aug 13, 2025, supports research to investigate conformational changes, post-translational modifications, and novel regulatory factors that control NLRP3 inflammasome activation and prevent excessive inflammation. Key objectives include improving the resolution of cryo-EM maps, verifying post-translational modification sites, and characterizing the roles of new regulatory proteins that interact with NLRP3. This work, to be performed by the awardee, The Children's Hospital Corporation (doing business as Boston Children's Hospital), is expected to provide valuable insights into NLRP3 biology and its role in various diseases, potentially aiding the development of targeted therapies for inflammatory and autoimmune conditions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $122.5k | 8/12/25 |