Project Grant R01AI189741
- This federal Project Grant award for $571,071.00, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand and develop protective measures against enterotoxigenic E. coli (ETEC) infections in infants. ETEC is a leading cause of diarrhea that is associated with significant morbidity, mortality, and stunting in children. The award will fund research at The Johns Hopkins...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $400,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Baylor College of Medicine in Houston, Texas. The funding will support pre-clinical studies to test the prophylactic efficacy of a potential vaccine against extraintestinal pathogenic E. coli (ExPEC), a member of the human microbiome that has become a leading cause of antibiotic-resistant mortality worldwide. The research...
- This Project Grant award, valued at $778,829.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Emory University. The grant supports research to characterize early-life B-cell and antibody-secreting cell (ASC) development and function, with the goal of uncovering the mechanisms of adaptive immunity at birth. The research aims to validate previous findings on the role of the spleen in...
- The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, awarded a $192,260 Project Grant under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to the Rector & Visitors of the University of Virginia. The grant will fund research to characterize the systemic and mucosal immune response to adenovirus 40/41 infection in Bangladeshi children and determine the efficacy of breast milk antibodies in providing...
- This $402,731 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), authorized under the Allergy and Infectious Diseases Research program (CFDA 93.855), will fund a program to increase the number of next-generation physician-scientists who can apply knowledge of microbiology, immunology, and research techniques to improve reproductive, maternal, and child health. The award will support 4 physician-scientists in pediatrics or obstetrics/gynecology residency...
- This $451,000.00 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) federal grant program, supports research to investigate the manipulation of antibody responses by a retrovirus. The research aims to enhance understanding of how pathogens can directly or indirectly modulate B cells, which play a critical role in providing long-term protective immunity. Specifically, the study will examine...
- This federal Cooperative Agreement award for $401,250.00 was granted by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The purpose is to conduct research on "Antibiotics, Innate Immunity, and Dysbiosis in Pediatric Urticarial Reactions." The project aims to study antibiotic-associated reactions (AARs), including serum sickness-like reactions (SSLRs), which occur in 5-10% of children and cause...
- This federal Project Grant award for $477,406.00, awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research), will fund research to verify the use of pigs as an appropriate model for developing human vaccines that target the entero-mammary pathway to elicit a robust secretory IgA (sIgA) immune response in human milk. The research aims to understand the critical role of sIgA in protecting mucosal surfaces, including in breastfed...
- The Project Grant award of $197,646 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), supports research to enhance the function of bacteriophages (viruses that attack bacteria) as a potential treatment for antimicrobial resistant bacterial infections. The award recipient, the University of California, San Diego (UCSD), will conduct experimental evolution studies to identify genetic...
- This $430,375.00 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research on a novel inter-membrane lipid signaling mechanism in Gram-negative bacteria like E. coli and Pseudomonas aeruginosa. The research aims to elucidate how these bacteria can sense and respond to deficiencies in their outer membrane lipopolysaccharide (LPS) content, a critical component for...
This federal Project Grant award of $2,750,557.00, awarded on September 11, 2025 by the National Institute of Allergy and Infectious Diseases (NIAID), supports research under the Allergy and Infectious Diseases Research program (CFDA 93.855) to study how vertically transferred antibodies can protect newborn babies from Escherichia coli (E. coli) infection. The research, conducted by Children's Hospital Medical Center, aims to understand why neonatal E. coli infection is relatively rare in humans despite universal early-life exposure, in contrast to the high susceptibility observed in laboratory mice. The project will investigate the role of "natural" anti-E. coli antibodies transferred from mothers to their newborns, which may confer protection against invasive infection. The findings from this 4-year research project could lead to improved understanding of neonatal immunity and the development of strategies to prevent serious E. coli infections in newborns.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.8m | 9/11/25 |