Project Grant R01AI193143
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $173,416 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Regents of the University of Michigan to conduct research on the integrated stress response (ISR) in macrophages during Salmonella enterica infection. The research aims to understand how host cell stress influences the innate immune response to this pathogen, which causes the global health burden of typhoid fever. The...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $3,519,992 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to the Sloan-Kettering Institute for Cancer Research. The grant, awarded on July 25, 2025, will fund research to understand the molecular mechanisms underlying "trained immunity" in natural killer (NK) cells and how chromatin architecture regulates this process during viral infections. The project...
- This federal Project Grant award, valued at $3,147,392.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research at the Childrens Hospital Medical Center in Cincinnati, Ohio to investigate how dendritic cells and the unfolded protein response (UPR) play a role in generating pathogen-specific Th17 immune responses. The research aims to advance the understanding of...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $3,613,118 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Seattle Children's Hospital, doing business as Seattle Children's Research Institute. The grant supports research to elucidate how the bacterial virulence factor hyaluronidase (HYLB) modulates immune responses and contributes to Group B Streptococcus (GBS) disease, including preterm births and neonatal disease. The...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $707,534 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Pennsylvania State University's Milton S. Hershey Medical Center. The grant supports research to understand the cellular mechanisms underlying mitophagy, the process of removing damaged mitochondria, and how disruptions in this process can lead to inflammation through the cGAS-STING pathway. The 5-year project aims to...
- This $132,609 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The funding supports research by The Ohio State University to investigate the role of the septin cytoskeleton in repairing damage to the plasma membrane, which is critical for protecting cells and regulating their functions. The research aims to advance the fundamental scientific understanding of how cells use the...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $689,068 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to the University of Cincinnati. The grant aims to establish ex vivo growth systems for the host-obligate fungal genus Pneumocystis, which causes life-threatening pneumonia in immunocompromised patients. The proposed research will pursue two approaches: 1) a cell-free culture system guided by metabolomics to identify...
- The National Institute of Allergy and Infectious Diseases (NIAID), part of the U.S. Department of Health and Human Services, has awarded a $531,245 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Yale University. The 5-year grant, starting on January 13, 2025 and ending on December 31, 2029, will support research to investigate the structure and function of the sorting platform, a key component of the type III secretion system (T3SS) in pathogenic...
- This $578,093 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research on a novel human damage-associated molecular pattern (DAMP) receptor called CLEC17A and its murine counterpart CD209F/G, as well as their ligand GAPDH. The central hypothesis is that these receptors and ligand play a key role in the sterile inflammatory response to cell injury. The 5-year project,...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $881,303 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to The Children's Hospital of Philadelphia (CHOP). The grant, awarded on July 17, 2025, aims to use whole genome sequencing and diagnostic allele surveillance to determine the transmission and persistence dynamics associated with bacterial infections in neonatal intensive care units (NICUs). The project will...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $527,960 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Research Institute at Nationwide Children's Hospital. The 5-year grant, awarded on August 18, 2025, supports research to investigate how the enzyme glutathione reductase (GSR) regulates cell metabolism and signaling during neutrophil-pathogen interactions. The research aims to understand how GSR protects enzymes in glucose metabolic pathways from oxidative damage, facilitating ATP production for phagocytosis and NADPH for the respiratory burst in neutrophils during bacterial or fungal infections. The project will utilize genetically-modified GSR-deficient mouse models to study neutrophil function, ROS production, and microbicidal activity compared to wildtype controls.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $528.0k | 8/18/25 |