Project Grant R21AI199901
- Federal Project Grant Award Summary The California Institute of Technology received a $128,461 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) awarded on August 1, 2025, with completion anticipated by July 31, 2027. The research project, titled "Determining the Role of Antibody Epitope Specificity in Regulating Fc Effector Functions," integrates deep mutational scanning (DMS)...
- Federal Grant Award Summary The California Institute of Technology received a $467,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective May 11, 2026, with a completion date of January 31, 2031. This research initiative investigates the evolutionary origins and molecular mechanisms of symbiotic relationships between rove beetles (Staphylinidae) and ant colonies. The project...
- Federal Grant Award Summary The California Institute of Technology (Caltech) received a $109,076 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), with performance occurring from January 1, 2026, through August 31, 2028. This award funds structural investigation of the central components of the CD4+ T cell immunological synapse, specifically addressing how T cells engage and become activated by...
- Federal Grant Award Summary The California Institute of Technology received a $554,742 Project Grant from the National Science Foundation's Division of Emerging Frontiers under the Biological Sciences program (CFDA 47.074), effective October 1, 2025, through January 31, 2027. This collaborative research initiative will investigate the mechanisms by which mucus interacts with and shapes microbiomes across diverse organisms. The research will address three primary questions: what properties of...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the J. Craig Venter Institute, Inc. a Project Grant of $556,375 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 23, 2025, with a completion date of June 30, 2027. The research focuses on identifying the molecular determinants governing thermoadaptation and parasitic growth in Histoplasma capsulatum, a dimorphic fungal pathogen responsible for pulmonary and...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $429,000 Project Grant to the University of Texas Health Science Center at Houston under the Allergy and Infectious Diseases Research program (CFDA 93.855) on February 2, 2026, with a completion date of January 31, 2028. This award supports research applying spatial transcriptional analysis to investigate host-pathogen interactions during fungal infections. The project delivers advanced...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $438,038 to the Regents of the University of California, Berkeley, under the Allergy and Infectious Diseases Research program (CFDA 93.855) for a two-year project period running from July 15, 2025 through June 30, 2027. This Project Grant funds a molecular research initiative investigating the regulation of infectious spore formation in Coccidioides posadasii, the fungal pathogen...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of California, Davis a $441,204 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period February 13, 2026 through January 31, 2028. The award funds investigator-initiated biomedical research examining the mechanisms by which Candida albicans colonizes the gastrointestinal tract and subsequently disseminates to cause invasive...
- Federal Grant Award Summary The California Institute of Technology (Caltech) received a $222,026 Project Grant from the Institute of Bioenergy, Climate, and Environment under the Agriculture and Food Research Initiative (AFRI) (CFDA 10.310) on July 15, 2025, with a completion date of July 14, 2027. This research initiative characterizes plant-bacteria interactions at the cellular and molecular level to enhance crop resilience under drought stress. The project employs advanced microscopy and...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of California, San Diego a Project Grant of $718,637 under the Allergy and Infectious Diseases Research program (CFDA 93.855) for research focused on developing camptothecin analogs as "block and lock" agents for HIV. The award, effective February 24, 2026, through January 31, 2031, supports investigator-initiated research examining how topotecan and related camptothecin...
The California Institute of Technology received a $255,000 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) on June 8, 2026, with a completion date of May 31, 2028. The award supports early-stage technology development to enable rigorous and reproducible fungal metatranscriptomics in human vaginal samples. This research addresses a critical gap in infectious disease diagnostics, as fungal diseases cost the U.S. economy an estimated $11 billion annually, yet the pathogenesis of many fungal infections remains poorly understood due to the lack of reliable technologies for directly measuring fungal activity in clinical samples. The research initiative will focus on developing methodologies that overcome current limitations in sequencing fungal RNA directly from clinical samples, where fungal RNA represents a small fraction of total RNA content. The project will be conducted at Caltech's Pasadena, California campus. This award aligns with the NIAID program's mission to support investigator-initiated biomedical research aimed at establishing and improving research addressing infectious diseases, with funding supporting basic science investigations into pathogenic mechanisms and technological advances intended to improve understanding of disease mechanisms and public health outcomes.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $255.0k | 6/9/26 |