Project Grant 2545246
- The Massachusetts Institute of Technology (MIT) was awarded a $800,000 Project Grant from the National Science Foundation (NSF) to conduct collaborative research titled "Learning How Mucus Shapes and Maintains Microbiomes" from September 1, 2021 through August 31, 2026. Under the award, MIT researchers will work to advance understanding of the role that mucus plays in shaping and maintaining microbiomes. The research is funded through the NSF's Biological Sciences program (CFDA...
- This $100,000 Project Grant was awarded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) program. The grant supports collaborative research to study the multiscale flagellar dynamics of bacteria swimming through complex biological fluids like mucus. The project will combine mathematical modeling, computer simulations, and laboratory experiments to develop a comprehensive understanding of how bacteria propel themselves through viscoelastic...
- This $125,954 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports collaborative research examining the role of mucus in the success and range expansion of Cassiopea jellyfish and related species. Over the two-year award period ending December 2025, the research team will characterize the physical properties of Cassiopea mucus and the motility of plankton and stinging cells within it using mathematical and engineering tools. They will also...
- This $550,108 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to understand the molecular and mechanistic bases of biofilm microbial communities. The principal investigator's laboratory will take a systems biology approach to investigate how transcriptional networks regulate gene expression during biofilm development in fungi, bacteria, and archaea, with a focus on...
- The Regents of the University of California received a five-year, $2.4 million Project Grant from the National Science Foundation to support the research project "MIM: A Thermodynamic Theory of Microbiome Assembly, Adaptation and Evolution Evaluated Using Modular Microbial Environments" from October 1, 2021 through September 30, 2026. This grant is being administered under the NSF's Biological Sciences program (CFDA 47.074), which aims to advance the fundamental biological sciences and...
- This $1,230,301 federal Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports a multidisciplinary collaboration to explore the mechanical properties and genetic/biochemical basis of a potent adhesive biopolymer produced by bacteria. The research aims to provide a detailed mechanistic understanding of how these types of materials impart strong adhesion, with applications in developing biocompatible and water-tolerant adhesives. The award,...
- This National Science Foundation (NSF) project grant under the Engineering program (CFDA 47.041) will investigate the role of gut microorganisms in controlling human health by focusing on their interactions with the gut sugar polymer mucin. The $450,000 award, effective from September 1, 2025 through August 31, 2028, will use miniaturized models of synthetic gut bacterial communities to explore gut modifications by beneficial and pathogenic bacteria. The research aims to enhance understanding of...
- This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) provides $719,638 to Cornell University to conduct fundamental research on the nanomechanics of bacterial adhesion and growth on healthy and diseased human gut mucus. The research aims to determine how differences in the molecular structures of healthy and diseased gut mucus impact bacterial adhesion and biofilm formation. The project will use computational modeling and simulations to obtain...
- The National Science Foundation awarded a $996,521 project grant under the Biological Sciences program (CFDA 47.074) to the Carnegie Institution of Washington for the period of April 1, 2021 through March 31, 2024. The goal of the research project is to scale single-cell physiology studies to better understand community stability in the natural gut microbiome. As part of this work, Johns Hopkins University will expand its microbiome curriculum to additional middle schools in Baltimore County...
- This NSF Biological Sciences (CFDA 47.074) Project Grant award of $600,000 to Emory University will investigate how microbiome communities, which are communities of bacteria and other microbes that live in and on organisms, can resist change and transition to alternate states. The project will use the nematode worm Caenorhabditis elegans as a model host to better define the stability and properties of alternate microbiome states, as well as how factors like antibiotic treatment and host...
This federal Project Grant award of $554,742.00 from the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program funds collaborative research to investigate how mucus, the slimy gel lining wet surfaces in the body, shapes and maintains microbiomes. The research aims to address three key questions: what properties of mucus do microbes care about, how are microbes structured within mucus, and what are the processes by which microbiomes self-organize in mucus. This work combines expertise in mucus biochemistry, microbiome structure and molecular biology, and the biophysics of microbe-mucus interactions. The research could yield new strategies for protecting humans from infections and leveraging beneficial microbes to improve functions like food digestion and salt tolerance. The grant also supports developing citizen science initiatives, integrating research and education, and engaging students and teachers to create a diverse community of researchers and shift perceptions of mucus. The grant was awarded to the California Institute of Technology (Caltech) and is expected to run from October 1, 2025 through January 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $554.7k | 12/1/25 |