Project Grant R35GM164058
- Federal Grant Award Summary The California Institute of Technology received a $149,264 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective January 20, 2026 through September 24, 2028. This grant supports the development of a concise dearomative synthetic approach for quinolizidine natural product synthesis, with applications in pharmaceutical development. The research addresses a...
- Federal Grant Award Summary The California Institute of Technology (Caltech) received a $109,076 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), with performance occurring from January 1, 2026, through August 31, 2028. This award funds structural investigation of the central components of the CD4+ T cell immunological synapse, specifically addressing how T cells engage and become activated by...
- Federal Project Grant Award Summary The California Institute of Technology received a $554,742 Project Grant from the National Science Foundation's Division of Emerging Frontiers under the Biological Sciences program (CFDA 47.074), effective October 1, 2025, through January 31, 2027. This collaborative research initiative delivers fundamental scientific research investigating the mechanisms by which mucus shapes and maintains microbiomes across diverse organisms. The project addresses three core...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded UC Berkeley $441,375 under the Biomedical Research and Research Training program (CFDA 93.859) for a five-year project (April 1, 2026 – March 31, 2031) investigating the cellular and developmental mechanisms underlying animal responses to intracellular beneficial microbes. The research utilizes the sea anemone Aiptasia as a genetically tractable model organism to study the endosymbiotic...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded California Institute of Technology a Biomedical Research and Research Training (CFDA 93.859) Project Grant of $446,219 effective March 1, 2026, with completion targeted for December 31, 2030. This MIRA (Maximizing Investigators' Research Award) renewal supports the development of novel synthetic methodologies centered on carbocation chemistry, with primary emphasis on catalytically generated vinyl...
- Federal Project Grant Award Summary The California Institute of Technology received a $711,488 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded April 1, 2026, with completion targeted for March 31, 2031. This research initiative, titled "Leveraging Phenazine Cycling to Understand Maintenance Metabolism in Pseudomonas aeruginosa," will advance understanding of antibiotic...
- Federal Project Grant Summary The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded $500,000 to the California Institute of Technology under the Biological Sciences program (CFDA 47.074) on May 15, 2025, for a collaborative research initiative extending through April 30, 2028. This project merges metabolomics and isotope biogeochemistry methodologies to develop and validate a novel algorithm for quantifying metabolic carbon fluxes in environmental...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded $125,000.00 to the California Institute of Technology under the Biomedical Research and Research Training program (CFDA 93.859) for the period April 1, 2026 through March 31, 2028. This K99/R00 Pathway to Independence award supports research focused on predicting reactivity in complex chemical settings using machine learning (ML). The project integrates high-throughput experimentation (HTE), ML...
- The National Science Foundation Division of Integrative Organismal Systems awarded a $499,872 Project Grant to the California Institute of Technology (Caltech) from August 15, 2021 to July 31, 2025. The grant supports research under the Biological Sciences program (CFDA 47.074) to develop Functional Genomic Tools for Parasitic Nematodes and Their Bacterial Symbionts. The Biological Sciences program aims to advance biological knowledge and understanding of major problems through basic research....
- Federal Project Grant Award Summary The California Institute of Technology received a $128,461 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) awarded on August 1, 2025, with completion anticipated by July 31, 2027. The research project, titled "Determining the Role of Antibody Epitope Specificity in Regulating Fc Effector Functions," integrates deep mutational scanning (DMS)...
The California Institute of Technology received a $467,500 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded May 11, 2026, with completion targeted for January 31, 2031. This research initiative investigates the evolutionary architecture of symbiotic species interactions, specifically examining how free-living rove beetles (Staphylinidae) transition into obligate symbionts dependent on ant colonies. The project will deliver fundamental scientific knowledge on the molecular, cellular, and genetic mechanisms underlying this evolutionary transformation. The research will produce insights across four integrated research areas: (1) the evolution of cellular and biochemical innovations enabling chemical interactions between rove beetles and ants; (2) the cellular basis for symbiotic integration through changes in pheromonal biosynthesis and chemosensory mechanisms; (3) the genetic basis for symbiotic irreversibility through epistatic interactions; and (4) reconstruction of evolutionary steps in the symbiotic transition. By leveraging the high frequency of free-living-to-symbiotic transitions in rove beetles as a model system, this work will advance understanding of how interspecies relationships originate and evolve—knowledge with potential biomedical applications for understanding beneficial and harmful symbioses affecting human health.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $467.5k | 5/7/26 |