Project Grant R21AI193607

Award Date 7/15/25
Completion Date 6/30/27
Dollars Obligated $438K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
California, USA
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This Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) provides $442,470.00 to the University of California, Merced to investigate the role of regulatory T cells in controlling immune responses to Coccidioides infection, which causes Valley Fever. The research aims to define the mechanistic relationship between regulatory T cells and the body's ability to clear Coccidioides fungal infections, in order to improve diagnosis,...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $556,375 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the J. Craig Venter Institute, Inc. (JCVI) on July 23, 2025. The grant, titled "Identifying the Molecular Determinants of Thermoadaptation and Parasitic Growth of Histoplasma capsulatum", aims to sequence and assemble approximately 150 new clinical isolates of the fungal pathogen Histoplasma capsulatum. The goal is to identify...
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This federal Project Grant award of $616,588 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will support research by The Regents of the University of California, San Francisco (UCSF) to exploit a high-precision phenotypic map to illuminate environmental sensing mechanisms of the fungal pathogen Cryptococcus neoformans, which causes fungal meningitis. The research aims to 1) dissect the function of new components of key...
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This Project Grant award of $247,621.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will fund an exploratory study by The Leland Stanford Junior University to evaluate whether pesticides, particularly fungicides and rodenticides, are geographically and temporally linked to human coccidioidomycosis (Valley Fever) cases or the environmental presence of the causative fungus, Coccidioides, in...
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The University of Southern California (USC) received a $623,986 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The funding supports a research project to study the genetic and molecular mechanisms that enable fungi, specifically the opportunistic pathogen Saccharomyces cerevisiae, to persist and cause infections in mammalian hosts. Key objectives include: Identifying causal...

The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $438,038 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Regents of the University of California, Berkeley to conduct research on the regulation of infectious spore formation in the fungal pathogen Coccidioides posadasii. The project aims to use experimental and computational genomic approaches to study how Coccidioides, the causative agent of Valley Fever, preferentially forms infectious spores in dry environmental conditions. The goal is to pinpoint candidate genes underlying spore formation and discover other environmentally-triggered phenotypes in Coccidioides to better understand disease transmission from the environment. The project will run from July 2025 through June 2027.

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