Project Grant R21AI199818
- Federal Grant Award Summary Award Details: The National Institute of Allergy and Infectious Diseases (NIAID) awarded Massachusetts General Hospital a Project Grant of $436,454 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on February 6, 2026, with a project completion date of January 31, 2028. Products and Services: This award funds investigator-initiated biomedical research investigating the gastrointestinal tract's role in systemic alloimmunity following allogeneic...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Massachusetts General Hospital a $453,750 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 1, 2025, through July 31, 2027. The award funds research investigating neutrophil swarming mechanisms in response to Pseudomonas aeruginosa microcolony aggregates. The research will develop an ex vivo model to elucidate the cellular and molecular...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Massachusetts General Hospital $197,240 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on September 3, 2025, for a mentored career development project investigating mechanisms of innate immune pathway activation by fungal extracellular vesicles. The award supports a two-year research initiative (completion date: August 31, 2027) focused on understanding how Candida...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Massachusetts General Hospital $160,954 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on January 29, 2026, with a completion date of July 31, 2026. This Project Grant supports investigator-initiated biomedical research focused on defining the mechanisms by which human macrophages kill the intracellular bacterial pathogen Shigella flexneri, a leading cause of...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $197,640 to Massachusetts General Hospital under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 16, 2025, for a five-year project period concluding June 30, 2030. This Project Grant funds investigator-initiated research to advance understanding of sepsis immunopathogenesis through single-cell ribonucleic acid sequencing (scRNA-seq) and functional immunological...
- Federal Project Grant Award Summary Massachusetts General Hospital received a $676,666 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective September 3, 2025, with a completion date of August 31, 2030. The award funds research into spatial and temporal adjuvant delivery mechanisms designed to enhance messenger RNA (mRNA) vaccine efficacy and durability. The project will...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Massachusetts General Hospital $428,598.42 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective July 1, 2025, through September 26, 2025. This Project Grant supports biomedical research investigating the mechanisms by which extracellular matrix (ECM) stiffness regulates the NLRP3 inflammasome in macrophages. The research addresses a critical gap in...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Massachusetts General Hospital a Project Grant of $798,107 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective February 3, 2026, with a completion date of January 31, 2031. This research initiative employs a tissue-based approach to understand tuberculosis-associated lung fibrosis, also known as post-TB lung disease (PTLD), which substantially contributes to...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $776,034 Project Grant on February 9, 2026, to Massachusetts General Hospital (The General Hospital Corporation) to conduct investigator-initiated biomedical research under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research will be conducted through January 31, 2031, at the hospital's Boston, Massachusetts location. This award supports fundamental...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Massachusetts General Hospital $453,750 on June 17, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop an innovative high-throughput airway organoid screening platform. This research project, scheduled for completion by May 31, 2027, focuses on identifying novel mechanisms of communication between airway epithelial cells (AECs) and intraepithelial...
Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Massachusetts General Hospital a $228,462 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on May 20, 2026, with a completion date of April 30, 2028. This award funds the development and validation of LYGENS (lysosome-targeting antigens), a modular platform that enhances antigen delivery to lysosomes for improved major histocompatibility complex class II (MHC-II) antigen presentation and CD4 T cell responses. The research deliverables include the design and testing of prototype constructs fusing microbial antigens from Listeria monocytogenes and Mycobacterium tuberculosis to lysosomal trafficking receptor ligands, with outputs measured through immunofluorescence, T cell reporter assays, and targeted immunopeptidomics analyses. The second phase of the project delivers engineered "endotag-LYGENS" constructs designed to address signaling concerns associated with natural ligand use while maintaining trafficking efficiency. The overall research produces design specifications and validation data establishing the foundational platform for a new class of engineered antigens with potential broad applicability to cancer vaccines, infectious disease interventions, and autoimmunity treatments. The work leverages natural intracellular trafficking pathways and is designed for compatibility with existing vaccine technologies, positioning the platform for translational advancement.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $228.5k | 5/22/26 |