Project Grant K99AI185158
- This federal Project Grant award for $489,500 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research focused on identifying non-conserved regulatory elements in the cell wall stress response of the fungus Candida albicans and testing non-conserved protein regions to discover novel antifungal drug targets. Key objectives include characterizing a cell wall stress...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant of $197,640 under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), on July 16, 2025. This grant supports research to investigate the contribution of a novel monocyte transcriptional state, termed Monocyte Substate 1 (MS1), to sepsis immunopathogenesis and patient heterogeneity. The project will...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,193,457 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to the University of Massachusetts Medical School (UMASS Medical) to produce, validate, and provide relevant fungal antigens to the scientific community. The funding will support the manufacturing of crude antigenic preparations from various fungal pathogens, as well as the recombinant production and testing of 36...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $857,215 to HMH Hospitals Corporation (doing business as Hackensack University Medical Center) to conduct research on how the fungal pathogen Candida albicans adapts to different host environments, such as the oral and systemic infection niches. The research aims to decipher how the fungal acetylome, regulated by the...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $394,320 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to research how extracellular matrix (ECM) stiffness regulates the NLRP3 inflammasome in macrophages. The objective is to define the mechanisms by which ECM stiffness controls the NLRP3 inflammasome, which is relevant to...
- This $262,665 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) will support research to determine the genetic mechanisms underlying skin colonization by the emerging fungal pathogen Candida auris. The project aims to leverage the research team's molecular genetic tools and established in vitro and in vivo models to investigate clade-specific genetic circuitry that...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $265,650 Project Grant under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to HMH Hospitals Corporation, doing business as Hackensack University Medical Center, to study the effects of antifungal drug treatment and immune dysfunction on the evolutionary dynamics of the gut-colonizing fungus Candida glabrata. This research aims to provide insights into the population dynamics and drug...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $470,028 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to New York University (NYU) to conduct research on deciphering fungal pathogen-specific cell cycle mechanisms in order to fuel antifungal drug discovery. The 5-year grant, with a period of performance from August 21, 2025 to July 31, 2030, will focus on investigating two promising fungal cell cycle variations in the...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $179,140 Project Grant under the Allergy and Infectious Diseases Research Program (CFDA 93.855) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to establish the protozoan parasite Acanthamoeba as a modern model for studying infectious disease biology, comparative metabolism, and mitochondrial molecular biology. The 5-year research and career development plan, led by Dr....
- This Project Grant award of $258,990.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The grant supports research conducted by The Children's Hospital Corporation (doing business as Boston Children's Hospital) to examine the role of the Candida albicans TOR1 kinase and its N-terminal heat repeats in enabling this fungal pathogen to withstand oxidative stress from the host...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), provides $197,240 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to conduct research on the mechanisms by which fungal extracellular vesicles activate the innate immune system's interferon signaling pathways. The research aims to elucidate the role of the STING pathway in the host response to fungal infections, particularly Candida albicans, and explore the functional consequences of this immune activation. The award period runs from September 3, 2025 to August 31, 2027. The research will involve training the principal investigator in advanced techniques for extracellular vesicle isolation, characterization, and analysis, as well as conducting in vitro and in vivo studies to understand the underlying biology.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $197.2k | 9/3/25 |