Project Grant R21AI187948
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $179,140 Project Grant under the Allergy and Infectious Diseases Research Program (CFDA 93.855) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to establish the protozoan parasite Acanthamoeba as a modern model for studying infectious disease biology, comparative metabolism, and mitochondrial molecular biology. The 5-year research and career development plan, led by Dr....
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant of $197,640 under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), on July 16, 2025. This grant supports research to investigate the contribution of a novel monocyte transcriptional state, termed Monocyte Substate 1 (MS1), to sepsis immunopathogenesis and patient heterogeneity. The project will...
- This $430,760 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID), which administers the Allergy and Infectious Diseases Research program (CFDA 93.855), to the University of Pittsburgh. The grant supports research to train neutrophils, a type of white blood cell, to defend against a lethal bacterial infection of the lung caused by Pseudomonas aeruginosa. The key objectives are to establish a strategy to improve the host's immune defense against this...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $151,040 Project Grant under the Allergy and Infectious Diseases Research Program (CFDA 93.855) to The Children's Hospital Corporation (doing business as Boston Children's Hospital) for the project "Investigating the Regulatory Impact of the Small Regulatory RNA BECO on Essential Virulence Factors in Pseudomonas Aeruginosa". This grant aims to investigate how the small regulatory RNA BECO regulates the...
- This Project Grant, valued at $868,776.00 and awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), supports research to characterize a novel post-transcriptional regulator in the opportunistic pathogen Pseudomonas aeruginosa. The key objectives are to identify the direct regulatory targets of this regulator, called PhAF, under standard laboratory conditions and in clinically relevant...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $779,915 Project Grant to the Scripps Research Institute to investigate the chromatin remodeling functions of polyphosphate condensates in the bacterial pathogen Pseudomonas aeruginosa. The grant, awarded under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), will support research to understand how polyphosphate, a polymer produced by bacteria in response to stress, interacts with the...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $807,330 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct research focused on improving antibody-based protection against Plasmodium falciparum (P. falciparum) and Plasmodium vivax (P. vivax) malaria. The project aims to identify new antibody variants with at least...
- This $453,750 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID), as part of the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), with an award date of June 17, 2025 and an ultimate completion date of May 31, 2027. The grant supports research to define novel mechanisms of communication between airway epithelial cells and intraepithelial airway macrophages, using an innovative high-throughput airway organoid screening...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $800,005 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct research on the structural basis and functional impacts of genetic variants in G-protein coupled receptors (GPCRs) associated with autoimmune diseases. The project aims to: 1) define the structural basis for impaired...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $105,076 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Trustees of Dartmouth College to study the dual function of the T6SS immunity protein TSIT in regulating Pseudomonas aeruginosa biofilm growth. The research aims to test the hypothesis that TSIT acts as a transcription factor, in addition to its role as a T6SS immunity protein, to regulate biofilm formation - a key...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $453,750 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), for research on Pseudomonas aeruginosa infections and neutrophil swarming behavior. The funding will support a 2-year project to develop an ex vivo model to study how neutrophils coordinate to surround and neutralize large bacterial targets like Pseudomonas biofilms. This research aims to reveal new therapeutic strategies for treating intractable Pseudomonas infections, which have become an increasing burden due to rising antimicrobial resistance. The project will be conducted at MGH's facilities in Boston, MA.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $453.8k | 7/28/25 |