Project Grant F32AI188955
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) program, is supporting research to investigate the role of the protein synaptopodin during bacterial infection by Shigella flexneri. The $2,637,034 award to the University of Colorado-Denver aims to examine how synaptopodin contributes to the spread of S. flexneri and other intracellular pathogens between host cells. The research...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand how the human-adapted Salmonella enterica serovar Typhi (S. Typhi) pathogen activates the Integrated Stress Response (ISR) in host macrophages and how this impacts the innate immune response and infection outcomes. The $173,416 grant, awarded on January 18, 2025, will fund the...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is funding research to investigate the mechanisms by which bacterial cholesterol-dependent cytolysins (CDCs) activate the NLRP3 inflammasome, a key innate immune signaling complex responsible for triggering inflammation. The $506,394 award, effective from January 24, 2025 through December 31, 2029, will support studies using...
- This Project Grant award of $249,000 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) program, is funding research to define the mechanisms by which macrophages restrict the growth of Klebsiella pneumoniae (KP) during bacteremia and sepsis. The central hypothesis is that tissue-resident macrophages provide distinct niches that restrict or permit KP in a manner dependent on bacterial initiation of cell death...
- This $174,767 Project Grant from the National Institutes of Health's National Institute of Allergy and Infectious Diseases will fund research into host defense mechanisms of resident peritoneal macrophages. Specifically, the awardee, Washington University, will examine how large peritoneal macrophages interact with mesothelial surfaces and promote clotting in the peritoneal cavity. This appears aimed at better understanding the immune response against infections and tumors in the peritoneum. The...
- This Project Grant award of $233,250.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will fund research to determine the role of the Brucella TIR-NAD hydrolase activity in immunosuppression and pathogenesis. The research will focus on the Brucella species, which are highly pathogenic for humans, to test the hypothesis that TIR-mediated NAD+ hydrolysis directly contributes to bacterial...
- This Project Grant award of $104,262, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to explore the relationship between genetic variants, transcriptional responses, and tuberculosis (TB) infection outcomes in macrophages derived from genetically diverse mice. The project aims to understand the basis for variability in TB infection outcomes, which may help identify ways to...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $204,347 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the University of Vermont & State Agricultural College to study the intracellular colonization strategies of Salmonella enterica serovar Typhimurium within human intestinal epithelial cells and macrophages. The research aims to characterize bacterial and host transcripts during Salmonella infection, distinguish between cytosolic and...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $132,677 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Icahn School of Medicine at Mount Sinai (ISMMS) to conduct research on mapping genetic variants associated with inflammatory bowel disease (IBD) to their target genes and functional effects in human macrophages. The project aims to elucidate the transcriptional consequences of IBD candidate genes in monocytes and...
- This Project Grant award, valued at $127,527.00 and running from November 1, 2025 to April 30, 2028, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The funding supports research by Duke University to investigate the role of the RGS12 gene locus in regulating macrophage function, particularly in the context of granuloma formation during mycobacterial infections like...
This Project Grant award for $160,954.00, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to define the mechanisms of macrophage-specific killing of the intracellular bacterial pathogen Shigella flexneri. The research aims to better understand how macrophages, a key immune cell, restrict and eliminate this leading cause of diarrheal disease and dysentery worldwide. The work will investigate the role of inflammasomes, cytosolic signaling complexes, as well as caspase-1, caspase-4, and gasdermin-D in macrophage-mediated control of Shigella infection. This research will provide critical insights into host-pathogen interactions and could inform the development of improved therapeutic approaches against shigellosis.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $80.5k | 7/23/25 | ||
| Not listed | $80.5k | 7/23/25 | ||
| Not listed | $0 | 7/23/25 |