This federal Project Grant award of $578,093 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) supports research to elucidate the structure and function of a novel damage-associated molecular pattern (DAMP) receptor, CLEC17A, in humans and its murine counterpart CD209f/g. The research aims to determine how these DAMP receptors on innate immune cells sense and respond to the release of the DAMP ligand GAPDH from injured cells,...
This Project Grant award, totaling $831,755, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to New York University School of Medicine. The funding supports research to investigate the role of lung-resident macrophage subsets, particularly nerve- and airway-associated macrophages (NAMs), in regulating type 2 immune responses and trained immunity following infections that trigger a robust...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research on the regulation of mitophagy and inflammation by the protein ZFAND6. The $707,534 award to Pennsylvania State University, Milton S. Hershey Medical Center will fund a 5-year study investigating the mechanisms by which ZFAND6 regulates mitophagy, inflammation, and the NLRP3 inflammasome. The research aims to provide new...
This federal Project Grant award, totaling $472,210.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The purpose of the award is to investigate the spatiotemporal relationship between CD4+ T resident memory cells and neutrophil recruitment in the lungs during pneumonia, while developing a transcriptional atlas of immune processes in the experienced lung. Key objectives include...
This Project Grant award, provided by the National Science Foundation's (NSF) Engineering program (CFDA 47.041), will support research at the University of Colorado (CU) to investigate how the mechanical properties of the extracellular matrix regulate the function of neutrophils, a key type of innate immune cell. The $646,451 award, effective June 1, 2025 through May 31, 2030, will enable CU researchers to decouple the roles of viscoelasticity and stiffness in modulating the neutrophil response,...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $244,440.00 to the Albert Einstein College of Medicine to conduct research on how Ly6C+ monocytes respond to and help clear microbial pathogen infections. The research aims to define the chemotactic cues, receptors, and mechanisms involved in how these monocytes home to infection sites and form stable clusters to deliver local...
This federal Project Grant award of $479,249, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to study the molecular mechanisms regulating neutrophil proinflammatory activity in sepsis. The key objectives are to: Determine the molecular basis of neutrophil A20 signaling in regulating neutrophil proinflammatory function under septic conditions. Utilize two-photon intravital...
This Project Grant award of $406,250.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to investigate the role of mechanical cues in the extracellular matrix in regulating monocyte inflammation. The project aims to develop human stem cell-based culture systems for studying monocyte mechanobiology, investigate the mechanical regulation of non-canonical NF-kappa-B signaling both in vitro...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $143,450 to support research on developing therapies for treating viral-induced acute lung injury. The primary focus is on evaluating the therapeutic efficacy of combinations of PPARG agonist and RXR ligand compounds in cotton rat models of influenza and respiratory syncytial virus (RSV) infection. The research...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $453,750.00 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to develop a novel CRISPR-based airway organoid screening platform. The objective is to identify key mechanisms of communication between airway epithelial cells and intraepithelial airway macrophages, which play important...