This federal Project Grant award for $492,000.00, awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research), will support research to investigate the mechanisms governing immunogenic cell death. The project aims to systematically study key "blind spots" in the understanding of the three sequential stages of immunogenic cell death: cellular uptake, damage-associated molecular pattern (DAMP) release, and pattern...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $667,013 to The University of Texas Southwestern Medical Center to develop and validate deep learning models for accurately identifying antibody-antigen interactions and binding epitopes from massive sequencing data. The research aims to leverage recent advancements in high-throughput sequencing, protein structure prediction, and single-cell...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $851,200 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Medical College of Wisconsin, Inc. The purpose of this award is to determine how the PTPN22 gene regulates the balance between interleukin-21-producing CD4 T cells and regulatory T cells, and how this impacts the development of type 1 diabetes. The award period runs from June 1, 2024 to April 30, 2026. This research...
This $864,735 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to identify novel mechanisms for generating antiretroviral antibody responses. The award will fund studies to elucidate the genetic and immunologic basis of a TLR7-independent pathway for antibody production in response to retroviral infections, using murine models. The findings from this 2-year...
This $478,800 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will support the development of a new class of small molecules to induce protein phosphorylation. The award recipient, The Broad Institute, Inc., will work to create "phosphorylation editing chimeras" that use kinase inhibitors to recruit and activate kinases to phosphorylate target proteins on demand. This research aims to advance...
This federal Project Grant award in the amount of $1,179,316.00 was issued by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award is focused on understanding the mechanisms that regulate CD8 T cell responses during chronic viral infection, with the goal of improving immunotherapies to increase T cell function and reduce viral load. Key aspects of the research include:
Determining the role of...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand the role of cells, antigens, and antibodies in controlling virus infections through antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytolysis (CDC). The $318,085 award, running from December 2024 to November 2029, aims...
This $306,500 Project Grant was awarded on July 22, 2024 by the National Institute of Allergy and Infectious Diseases (NIAID), part of the Department of Health and Human Services, under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The grant supports Qrono, Inc., a for-profit company specializing in medical research and development, in developing QR402 - a first-in-class, oral nanomedicine that targets dendritic cells to activate the AMPK pathway as a...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant (CFDA 93.855) totaling $239,348 to The Trustees of Columbia University in the City of New York. The award, with a period of performance from January 17, 2025 to December 31, 2026, will support research to investigate a newly identified population of CD1a-restricted T cells that respond to phosphatidylglycerol (PG), a lipid antigen shared between bacteria and mammalian cells. The research aims to...
This federal Project Grant award in the amount of $631,977.00, awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) on November 18, 2024, supports research to enhance immunological memory and pathogen control through nutritional interventions.
The key objectives are to: (I) reveal how caloric restriction can be utilized to enhance pathogen- and vaccine-elicited immunological memory, and (II) develop novel therapies that...