This $172,909 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) funds research to uncover the role of the mitochondrial membrane phospholipid cardiolipin in promoting inflammatory cell death pathways. The overarching goal is to define the molecular mechanisms by which disruptions in mitochondrial homeostasis, including those driven by the LRRK2G2019S mutation, trigger the...
The federal Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research into the role of the sigma factor SigE in mycobacterial granulomas. This $207,370 award to Duke University, effective from September 21, 2024 through March 31, 2027, aims to uncover novel bacterial elements that impact the survival of mycobacteria within granulomas and the associated host...
This $320,788 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research at the University of Washington to investigate the role of antigen-independent T cell activation in controlling Mycobacterium tuberculosis (M.tb) infection, which causes tuberculosis (TB). The research aims to determine the ability of CD1a/b/c-restricted T cells to undergo bystander activation and...
This $162,512 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to understand how pathogen exposure and inflammation drive the expansion and function of long-lived effector CD8 T cells in the memory compartment. The key research objectives are to: 1) Determine what pro-inflammatory cytokines support the formation and persistence of long-lived effector CD8 T cells,...
This Project Grant award, valued at $151,531, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports research to investigate the mechanisms of reverse transcriptase-mediated phage defense systems in Enterobacteriaceae, a group of multidrug-resistant bacteria that pose a significant public health threat. The project aims to develop an experimental approach to discover the RNA...
This Project Grant award, valued at $187,398, was issued by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports research to investigate the role of Programmed Death Ligand-1 (PD-L1) and CD80 in regulating dendritic cell migration and T cell priming. Specifically, the research aims to: 1) Define the extracellular interactions between PD-L1 and CD80 that govern dendritic cell migration, and...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides funding of $857,346.00 to the Fred Hutchinson Cancer Center in Seattle, Washington. The award supports research to investigate how activating and inhibitory signals, such as cytokines and metabolites, regulate the function of CD8 T cells in healthy and infected human tissues. The goal is to better understand how immune...
This federal Project Grant award, valued at $499,746 and awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to uncover the genetic basis and molecular mechanisms underlying T cell propensity towards autoimmunity. The award supports research to 1) elucidate the role of mitochondrial cristae morphology regulation in effector T cell functions, 2) understand the relationship between mitochondrial...
This federal Project Grant award, valued at $104,552.00 and awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program, funds research aimed at understanding how the tuberculosis-causing bacterium Mycobacterium tuberculosis (MTB) is able to survive and thrive within human neutrophils, the most abundant immune cells recruited to sites of MTB infection. The key objectives of this project are to: 1)...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $182,084 to fund research on the role of prostaglandin E2 in Listeria monocytogenes-induced CD8+ T-cell priming. The research aims to identify bacterial determinants of prostaglandin E2 induction, define the signaling pathways and cell types impacted by prostaglandin E2 to promote CD8+ T-cell priming, and...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $239,348 to support research into CD1a-restricted T cells that recognize the lipid antigen phosphatidylglycerol (PG). The research aims to investigate the conditions under which mitochondrial PG becomes visible to these T cells, as well as compare the antigenicity of mammalian versus bacterial PG. Single-cell RNA and T cell receptor sequencing will also be used to determine if CD1a-PG specific T cells constitute a distinct T cell subset. This research seeks to understand the origins and immune implications of this shared bacterial and mitochondrial T cell antigen, which could have relevance for autoimmune or inflammatory conditions involving mitochondrial lipids. The award period runs from January 17, 2025 to December 31, 2026 and is being carried out by the Health Sciences Division of The Trustees of Columbia University in the City of New York.