This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $729,047 to The Medical College of Wisconsin, Inc. to investigate the GATA2-TGF-β-TAL1 pathway as a critical mediator of natural killer (NK) cell development. The project aims to uncover a novel transcriptional network essential for human NK cell development and functions, with the goal of understanding disease...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $870,800 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the University of Wisconsin - Madison. The grant will fund research to understand the heterogeneity and function of human induced pluripotent stem cell (iPSC)-derived neutrophils and their potential for antimicrobial effects. Specifically, the researchers will use single-cell multi-omics and optical metabolic imaging to analyze the...
The Medical College of Wisconsin, Inc. (MCW) was awarded a $1,046,468 Project Grant by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420). The grant, awarded on July 1, 2023, will fund research to investigate chemotherapy dosing in obese patients, with the goal of optimally balancing risks and benefits to avoid overtreatment and undertreatment. The research will be conducted at MCW's facilities in Milwaukee, WI and is expected to be completed by...
This federal Project Grant award, totaling $217,698.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports research to investigate how human leukocyte antigen (HLA) risk alleles contribute to the development of type 1 diabetes (T1D) by influencing the selection of T cell receptors (TCRs) that recognize pancreatic beta cell antigens. The research aims to (1) define how...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $682,879 to The Medical College of Wisconsin, Inc. to conduct research on the impact of human cytomegalovirus (HCMV) infection on developing human neural tissues and brain function. The research aims to: 1) define the transcriptional and cellular disruptions to developing human neural cells caused by HCMV...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $182,084 to the University of Wisconsin-Madison to investigate the role of prostaglandin E2 (PGE2) in mediating CD8+ T-cell responses to the bacterial pathogen Listeria monocytogenes. The research aims to identify bacterial determinants that induce PGE2 production, determine how PGE2 signaling promotes CD8+ T-cell...
The University of Chicago was awarded a $884,454 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant, awarded on June 6, 2024, supports research to perform clonal analysis of naturally occurring IL-10-producing TR1 regulatory T cells in mice. The objectives are to define the T cell receptor (TCR) repertoire, reactivity, differentiation trajectory, and transcriptional profile of...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $287,000 in funding to The Regents of the University of California, San Francisco (UCSF) to determine whether genetic mutations that alter IL-17 signaling contribute to the etiology of autoimmune diabetes. The research aims to understand the mechanism by which altered IL-17 signaling leads to autoimmune...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA 93.859 - Biomedical Research and Research Training, provides $390,000.00 to The Medical College of Wisconsin, Inc. over a 5-year period from January 1, 2025 to December 31, 2029. The objective of this project is to improve the foundational knowledge of immune cell biology in vivo, focusing on the ontogeny, kinetics, and function of tissue-resident macrophages. The project will utilize a novel...
This federal Project Grant award of $578,093 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research into the immunobiology of a novel human DAMP receptor and its murine homolog, including their ligand. The award was made to the University of Massachusetts Medical School (UMass Medical), a prominent research institution and medical school experienced in securing federal grants and contracts....