The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $492,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Regents of the University of California, San Francisco (UCSF). The grant, with a period of performance from August 15, 2024 to July 31, 2029, supports UCSF's research to systematically investigate the mechanisms governing immunogenic cell death (ICD). The project aims to address key knowledge gaps in understanding the cellular processes that determine whether engulfed dead cells trigger an adaptive immune response or are consumed silently, which is critical for developing therapies for autoimmunity, cancer, and infectious diseases. The research will focus on three key areas: the mechanisms of calreticulin-independent cellular uptake, the release of damage-associated molecular patterns (DAMPs) and adjuvants by dead cells, and the regulation of pattern recognition receptor-driven antigen presentation in antigen-presenting cells.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $492.0k | 8/15/24 |