The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $166,000 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) federal grant program to the University of Southern California (USC). The objective of this 2-year project is to establish a high-throughput drug screening pipeline to identify selective inhibitors of pro-autoimmune Th17 cells, while also generating biotinylated clofazimine (CLF) to determine its molecular targets in these cells. This...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a 5-year, $571,091 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to President and Fellows of Harvard College, doing business as Harvard Medical School, to investigate the role of gut regulatory T (Treg) cells and their interactions with the gut microbiome. The research aims to understand how microbial and food antigens establish gut Treg phenotypes and T cell receptor repertoires, particularly...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $221,888 to the University of New Mexico Health Sciences Center to study the control of survival pathways in Th17 cells. The research aims to explore mechanisms for inducing Th17 cell apoptosis and evaluate potential applications of this approach using preclinical animal models. The award period runs from January 22,...
This Project Grant award of $194,740 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to characterize the development of lung-resident, self-antigen-specific regulatory T cells (Tregs) following acute lung injury. The goal is to understand how these "experienced" Tregs can promote tolerance and prevent future autoimmunity. The principal investigator, Dr. Daniel Shin at...
This federal Project Grant award for $246,623.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research at New York University School of Medicine to study the molecular control of tolerogenic dendritic cell function. The research aims to characterize the dendritic cell subset responsible for maintaining T cell tolerance, including investigating aberrant cytokine...
This federal Project Grant award of $586,250 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research at the University of Massachusetts Medical School (UMass Medical) to investigate the generation and regulation of TFH13 cells that drive pathogenic IgE in allergic conditions. The overarching goal is to elucidate the pathways leading to TFH13 cell differentiation, which play a critical...
This $751,138 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) supports research to determine how the metabolism of dendritic cells, a type of immune cell, regulates inflammatory immune responses. The central hypothesis is that the activity of the enzyme glutaminase in dendritic cells controls their ability to activate pro-inflammatory T cells versus regulatory T...
This Project Grant award of $647,187 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to investigate the role of heme synthesis in regulating regulatory T (Treg) cell fitness and function. The research aims to determine how the enzyme CPOX, critical for heme biosynthesis, promotes the proliferation, survival, and suppressive capacity of engineered Tregs. It also seeks to map the...
This Project Grant award of $790,222 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Program (CFDA 93.855) supports research by the Van Andel Research Institute (VAI) to investigate how the enzyme methionine adenosyltransferase 2A (MAT2A) regulates the differentiation and function of pathogenic T helper (Th) cells versus protective regulatory T (Treg) cells in the context of central nervous system autoimmunity, such as...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant valued at $718,758 to the Texas Biomedical Research Institute under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant is focused on evaluating the use of IL-21-IgFc fusion protein as a host-directed immunotherapy to improve immune reconstitution and reduce the risk of latent tuberculosis (TB) reactivation in Mycobacterium tuberculosis (MTB) and simian immunodeficiency virus (SIV)...