This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $221,888 to the University of New Mexico Health Sciences Center (UNM HSC) to explore mechanisms for inducing apoptosis in Th17 cells. The research aims to target the IRE1 and STAT3 pathways to diminish the pathogenic function of Th17 cells, which play a role in inflammatory and autoimmune diseases. The...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $417,984 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Scripps Research Institute in La Jolla, California. The grant, awarded on March 7, 2025, will support research to identify actionable targets for the selective induction of regulatory T cell (Treg) differentiation. The research aims to address a key knowledge gap in understanding the biology and application of naive CD4...
The University of Southern California (USC) received a $623,986 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The funding supports a research project to study the genetic and molecular mechanisms that enable fungi, specifically the opportunistic pathogen Saccharomyces cerevisiae, to persist and cause infections in mammalian hosts. Key objectives include: Identifying causal...
This $642,775 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will fund research to accelerate the discovery of novel antifungal peptides using one-bead one-compound (OBOC) combinatorial technology. The University of California, Davis will conduct high-throughput screening of chemically synthesized peptide libraries to identify membrane-active antifungal peptides that can...
This federal Project Grant award of $441,202.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research to investigate the role of ex-regulatory T cells (ex-Tregs) in autoimmunity and cancer immunity. The research aims to utilize a genetic Treg lineage tracing system to monitor ex-Tregs and test whether they are required for tumor control or the onset of autoimmune disease when...
This federal Project Grant award in the amount of $893,203.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports research to investigate the mechanisms by which the cytokine interleukin-17 (IL-17) protects kidney tissue from damage caused by the fungal infection Candida albicans. The research aims to define the role of the IL-17/NDUFS4 pathway in preventing mitochondrial...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $612,975.00 to fund research aimed at achieving long-term acceptance of organ transplants without the need for chronic immunosuppression. The research seeks to develop a translational model that combines T-cell costimulation blockade with inhibition of monocyte allorecognition via CD47 to induce long-term graft...
This federal Project Grant award, totaling $649,053, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports research at The Washington University in Missouri to investigate the role of Ly49 family receptors on CD8 T cells and their function in regulating immune responses. Specifically, the project aims to understand how Ly49 and the transcription factor Helios contribute to the...
The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded a $300,000 Project Grant to Electronic Biosciences, Inc. to develop a novel point-of-care technology for monitoring immunosuppressant drug levels. The key product being developed is a portable, fingerstick-based testing system that can provide convenient and frequent immunosuppressant drug level measurements. This will enable more precise dosing for...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $499,746 to support research aimed at uncovering the genetic and molecular mechanisms that link mitochondrial cristae integrity to T cell-mediated autoimmunity. The research seeks to 1) determine how mitochondrial cristae morphology is regulated in effector T cells, 2) understand the relationship between...