This $1,413,677 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to understand the complex interactions between the bacteria Pseudomonas aeruginosa and Staphylococcus aureus during polymicrobial infections. The research aims to define the mechanisms by which the P. aeruginosa exopolysaccharide Psl antagonizes S. aureus growth and interactions, as well as...
This federal Project Grant award in the amount of $205,000.00 was granted by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The primary objective of this 2-year project, running from April 2025 to March 2027, is to investigate the influence of chromosome copy number on Pseudomonas aeruginosa persister cells and their tolerance to fluoroquinolone antibiotics. The research will focus on characterizing...
This federal Project Grant award of $661,387 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports comprehensive research into the regulation and mechanisms of antibiotic resistance mediated by RND efflux pumps in the pathogenic bacterium Pseudomonas aeruginosa. The research program, conducted by Emory University in collaboration with the University of Texas at Austin, aims to uncover novel physiological aspects and the...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $868,776 to Boston Children's Hospital to characterize the regulatory functions of a novel post-transcriptional regulator called PHAF in the opportunistic pathogen Pseudomonas aeruginosa. The research aims to identify PHAF's direct regulatory targets, investigate its role in virulence and biofilm formation, and...
This $876,094 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research at The Ohio State University to investigate interactions between the opportunistic pathogens Pseudomonas aeruginosa and Mycobacterium abscessus. The research aims to identify the novel antibacterial mechanism by which P. aeruginosa antagonizes M. abscessus in dual-species biofilms, and to study...
This $261,107 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research to determine how the newly discovered regulator PA1627 controls the Type III Secretion System in Pseudomonas aeruginosa. The goal is to understand this new regulatory mechanism, which could lead to the development of new therapeutic approaches to combat this difficult-to-treat pathogen. The award...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research to examine the molecular determinants and functions of bacterial polysaccharide cellular localization in Pseudomonas aeruginosa (P. aeruginosa) biofilms. The key objectives are to: 1) analyze the chemical modifications and isoforms of the P. aeruginosa exopolysaccharides Psl and Pel; 2) investigate...
This $1,444,195 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to discover strategies to enhance the activity of topoisomerase inhibitors against antibiotic-resistant Escherichia coli and Pseudomonas aeruginosa pathogens. The key objectives are to: 1) identify metabolites that can modulate persistence and resistance development in these bacteria toward...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $246,590 to the University of California, San Diego (UCSD) to conduct research on nucleus-forming bacteriophages (phages) and their potential as therapeutic agents for Pseudomonas aeruginosa infections. The key objectives of this research project are to: 1) determine the structure and mechanism of the phage...
This $507,792 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to determine the role of the precursor HIV-1 protease enzyme in the development of drug resistance to protease inhibitors. The award will fund research to assess how specific mutations influence the dimerization and activity of the precursor and mature protease enzymes, evaluate whether protease inhibitor resistance...