This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is providing $661,387 to Emory University to conduct research on the regulation and mechanism of antibiotic efflux in the opportunistic pathogen Pseudomonas aeruginosa. The key products and services to be delivered through this 5-year grant include:
Uncovering novel aspects of P. aeruginosa physiology to define the cellular and molecular processes that lead to upregulation of the MexXY efflux system upon aminoglycoside antibiotic treatment. Additionally, the research will determine the molecular basis of aminoglycoside uptake, selection, and efflux through the MexXY-OprM transporter protein. This comprehensive understanding of P. aeruginosa's antibiotic resistance mechanisms is expected to identify potential new strategies for developing anti-Pseudomonal therapeutics. The research also has broader implications for understanding the biology and potential therapeutic targeting of RND efflux pumps in other important human pathogenic bacteria.
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