This Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the dynamics and evolution of HIV Gag and GagPol processing. The $752,745 award aims to use molecular dynamics simulations, single-molecule FRET imaging, and cryo-electron tomography to probe the structure and dynamics of Gag and GagPol that enable ordered processing by the viral...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $411,840 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Illinois to develop a computational toolkit for systematically dissecting protein drug resistance mechanisms against HIV. The goal is to leverage protein conformational dynamics to enable the rational design of effective counterstrategies to combat HIV drug resistance. The 2-year project will involve...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $617,376 to Emory University to conduct research aimed at elucidating the timing and regulation of HIV-1 protease autoactivation and viral maturation. The research leverages advanced imaging techniques, including total internal reflection fluorescence microscopy and correlative light-electron microscopy, to visualize single virus...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $220,224.00 to the University of Chicago to computationally investigate key morphological transitions in the HIV-1 life cycle. The research aims to improve understanding of the assembly and disassembly processes involved in HIV-1 infection, including virion budding, viral core maturation, and capsid uncoating. This...
This Project Grant award of $223,300.00, awarded on January 17, 2025 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to develop novel antiviral compounds targeting the HIV capsid protein. The goal is to generate compounds that can effectively inhibit HIV strains resistant to the recently approved capsid-targeting drug lenacapavir. Key aims include synthesis of analogs designed to...
The National Institute of Allergy and Infectious Diseases (NIAID) has awarded Colorado State University a $340,408 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop and validate an assay for precision antiretroviral therapy to combat drug resistance in HIV patients. The key products and services to be delivered under this award include: Improving the throughput and capacity of an existing infectivity assay using proviral constructs with an H2B-mRFP...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $859,992 to Yale University to conduct research on the molecular mechanisms underlying HIV-1 maturation. The research aims to: 1) determine the high-resolution structural pathway of HIV-1 Gag assemblies and capsid during maturation within their native cellular environment using cryo-electron microscopy and tomography...
This federal Project Grant award of $696,828, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to define the structural basis of HIV-1 cap hypermethylation and its linkage to viral post-transcriptional control and modulation of host innate immune signaling. Key objectives include elucidating the role of the HIV-1 Rev/RRE regulatory system in cap hypermethylation, and how...
This federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to better understand the molecular mechanisms of HIV spread through cell-cell contact across a virological synapse (VS). The $515,282 award will enable Case Western Reserve University (CWRU) to develop a novel flow cytometry assay for quantifying and purifying infected cell-target cell pairs, and leverage...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $624,902 to The University of Texas Health Science Center at San Antonio to investigate the role of the HIV accessory protein Vpr in facilitating viral persistence in myeloid cells. The research aims to characterize how Vpr induces epigenetic remodeling at HIV integration sites, which may reveal novel therapeutic...