Project Grant R21AG104687
Award Date 9/1/26
Completion Date 8/31/28
Dollars Obligated $440K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Houston, TX 77030, USA
Similar Awards
- The National Institute on Aging awarded Massachusetts Institute of Technology $723,962 on June 1, 2026, under the Aging Research program (CFDA 93.866) to conduct a systems-level analysis of DNA damage and repair in senescence, aging, and cancer. The research applies mass spectrometric adductomics and an in vivo host cell reactivation assay to define the spectrum of DNA adducts in human cells, identify adducts that accumulate in senescing cells and drive replication stress, assess how...
- The National Institute on Aging awarded The University of Texas MD Anderson Cancer Center $451,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to model age-dependent HSP90 decline and genome instability in mammals. The project examines how heat shock protein 90 (HSP90), a sentinel of protein homeostasis, buffers deleterious mutations in critical DNA repair proteins FANCA and BRCA1, and investigates how HSP90's buffering capacity diminishes with age. The research uses...
- This $1,031,595 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The awardee, Dana-Farber Cancer Institute, will define the landscape and mechanisms of protein redox regulation during aging. Specifically, the Institute will systematically map cysteine oxidation networks in mouse tissues to determine their role in coordinating protein complex assemblies relevant to age-related...
- The National Institute on Aging awarded Baylor College of Medicine $440,000 on May 1, 2026, under the Aging Research program (CFDA 93.866) to conduct single-cell transcriptomic and epigenomic analysis of budding yeast aging. The project, titled "Beyond Genetics: Unveiling Epigenetic Drivers of Lifespan Heterogeneity Through Yeast Single-Cell Aging Atlases," investigates the molecular basis for lifespan variation in genetically identical organisms raised in controlled conditions. The...
- This Project Grant award, provided by the National Institute on Aging under CFDA Program 93.866 - Aging Research, supports a $2,516,316 research initiative led by Harvard Medical School to investigate neuronal activity-responsive DNA repair mechanisms and their contribution to cognitive aging and Alzheimer's disease. The key products and services to be delivered under this 3-year grant include: Mapping the landscape of activity-induced DNA double-strand breaks (DSBs) in wild-type mice and...
- The National Institute on Aging awarded Baylor College of Medicine $1,343,997 on March 1, 2026, under the Aging Research program (CFDA 93.866) to generate tool compounds and chemical probes for putative Alzheimer's disease and related dementia therapeutic targets using DNA-encoded libraries and machine learning. The project will perform DEL selections on AD/ADRD targets, synthesize enriched DEL hits, and test them for activity. Baylor will share publicly the selection input of 12 DNA-encoded...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $533,500 to the Buck Institute for Research on Aging on July 15, 2026, under the Aging Research program (CFDA 93.866). The award funds examination of the role of autonomic innervation in muscle stem cell aging. The research investigates the functional link between autonomic nervous system neurons and muscle stem cells using Drosophila melanogaster as a model organism. The project will refine...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The University of Texas Southwestern Medical Center $249,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop and validate an innovative genetic platform for de-risking g-secretase modulator therapeutics in Alzheimer's disease. The award funds two primary aims. Aim 1 involves using CRISPR/Cas9 engineering and structure-informed design to generate and validate a novel...
- The National Institute on Aging awarded Cincinnati Children's Hospital Medical Center $445,500 on May 15, 2026, under the Aging Research program (CFDA 93.866) to conduct proteomic research on nuclear rupture-associated proteins in laminopathy hearts. The award funds systematic identification of proteins recruited to nuclear rupture sites in cardiomyocytes, using laminopathy-related dilated cardiomyopathy as a disease model. Work includes in vivo proximity labeling to identify candidate...
- The National Institute on Aging awarded the President and Fellows of Harvard College $125,901 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop a universal toolkit for single-cell somatic mutation detection and apply it to aging-related processes. The project addresses the challenge of detecting post-zygotic somatic mutations that accumulate throughout life and may contribute to aging and disease. While single-cell whole genome sequencing and duplex sequencing...