This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to President and Fellows of Harvard College (Harvard Medical School) for $466,125 will support research to investigate the effects of Alzheimer's disease (AD) on subcellular transcriptome dynamics and mitochondrial-nuclear (mitonuclear) coordination in neurons. The research aims to determine how AD pathology impacts the balance between the mitochondrial and nuclear genomes, as well as the...
This federal Project Grant award, valued at $6,226,692.00 and funded by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research to investigate the role of neuronal hyperexcitability and proteostasis in the progression of Alzheimer's disease (AD). The study aims to track early electrophysiological changes in the locus coeruleus (LC) and hippocampus (HPC) as key brain regions impacted by the accumulation of beta-amyloid and tau proteins. The research seeks to understand...
This Project Grant award from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) provides $835,825 to the University of Massachusetts Medical School to conduct research on somatic mutations in Alzheimer's disease. The project aims to analyze patterns of somatic single nucleotide variants, short insertions/deletions, and structural variants in neurons from Alzheimer's disease brains across disease progression. It will also examine how these...
The University of Massachusetts Medical School (UMass Medical) was awarded a $1,507,500 Project Grant from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to conduct a study on spatial single-cell analysis of somatic mutations in the human brain during aging and neurodegeneration. The goal is to develop and apply new single-cell whole-genome sequencing methods to study somatic mutations in neurons from late-stage Alzheimer's disease and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,001,864 to Harvard University to investigate the subcellular mechanisms underlying the selective vulnerability of specific neuron subtypes in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The researchers will quantitatively study the localization of RNA, proteins, and translational regulation in the synapses and soma of vulnerable corticospinal neurons (CSN) and...
This federal Project Grant award, provided by the National Institute on Aging (CFDA 93.866 Aging Research), will support research to identify susceptible cell types within the medial temporal lobe (MTL) that are impacted by Alzheimer's disease (AD) pathology. The $103,304 award, spanning August 1, 2024 to July 31, 2025, will utilize advanced viral tracing and microscopy imaging techniques to characterize 3D neural circuits originating from entorhinal cortex (ENT) neurons projecting to the CA1...
This $5,032,924 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the hypothesis that age-related accumulation of amyloid and prion-like proteins in human cells is driven by transcription errors induced by DNA damage. The primary awardee, the University of Southern California, will screen a database of transcription errors, test the amyloid-forming potential of identified proteins, and examine how DNA damage can generate...
This National Institute on Aging (NIA) Project Grant award under the Aging Research program (CFDA 93.866) provides $460,625 to the University of Massachusetts Medical School (UMass Medical) from September 30, 2024 to September 29, 2026. The project aims to gain a mechanistic understanding of the role of cellular senescence in the pathogenesis of Alzheimer's disease (AD). Researchers will use human induced pluripotent stem cell (iPSC)-based AD models to separately dissect the P53/P21 and P16...
This $343,440 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a study led by Dr. Lolita Nidadavolu at the Johns Hopkins University to investigate the role of cell-free DNA (cf-DNA) in microglial activation and inflammation in Alzheimer's disease (AD). The research aims to: 1) examine associations between serum cf-DNA levels and microglial activation in AD, and 2) study functional changes in microglia phagocytosis and pro-inflammatory pathway...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $146,922 provides funding to The Trustees of Columbia University in the City of New York to investigate the gene expression changes in hippocampal engram cells that underlie memory deficits in a mouse model of Alzheimer's disease. The research aims to identify the unique transcriptional signatures of engram cells during memory encoding, retrieval, and reactivation, and determine how...