Project Grant R21AG102442
- The National Institute on Aging awarded Beth Israel Deaconess Medical Center, Inc. $3,481,644 on August 1, 2026, under the Aging Research program (CFDA 93.866) to investigate mechanisms by which excessive amyloid-beta peptides impair brain lymphatic function and contribute to Alzheimer's disease and Down syndrome. The research program comprises three strategic aims. The first involves extensive molecular, cellular, structural, and functional analyses of brain lymphatics in mouse models of...
- The National Institute on Aging awarded Georgia TECH Research Corp $432,849 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop a three-dimensional microphysiological organoid-on-chip platform that models aged human germinal center dynamics and evaluates sex-specific determinants of immune aging in human lymphoid tissues. The project combines high-dimensional cyclic immunofluorescence mapping of aged human lymph nodes with an organoid-on-chip system designed to...
- The National Institute on Aging awarded Beth Israel Deaconess Medical Center, Inc. $761,496 on June 15, 2026, to investigate epigenetic mechanisms linking delirium and cognitive decline under the Aging Research program (CFDA 93.866). The recipient will test the hypothesis that epigenetic risk, measured by DNA methylation, identifies individuals with a vulnerable brain predisposed to delirium, cognitive decline, and Alzheimer's disease and Alzheimer's disease-related dementias in the setting of...
- The National Institute on Aging awarded New York University $6.203 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to examine peripheral immune markers and vascular dysfunction as contributors to cognitive decline and Alzheimer's disease. The research integrates circulating biomarkers—platelet aggregation, neutrophil activity, and proteomic data—with advanced imaging to assess associations between vascular and immune dysfunction and cerebrovascular burden, amyloid...
- The National Institute on Aging awarded Dana-Farber Cancer Institute, Inc. $1,526,573 on July 15, 2026, under the Aging Research program (CFDA 93.866) to conduct research on rejuvenation of aged hematopoietic stem cells and bone marrow niche function via mitochondrial engineering. The research addresses how aging impairs hematopoietic stem cell (HSC) transplantation success by driving mitochondrial dysfunction in donor cells. The work investigates mitochondrial transfer between HSCs and...
- The National Institute on Aging awarded Albert Einstein College of Medicine $462,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate chaperone-mediated autophagy in aging-associated cardiovascular fibrosis. The research examines the role of declining chaperone-mediated autophagy (CMA) activity in fibroblasts as a driver of progressive fibrotic remodeling in aging hearts and vessels. The study will test whether age-related CMA decline in cardiac fibroblasts...
- The National Institute on Aging awarded Tufts Medical Center Parent, Inc. (doing business as Tufts Medical Center) $357,000 under the Aging Research program (CFDA 93.866) on September 1, 2026, to investigate endothelial pannexin1-induced inflammation in Alzheimer's disease. The research tests the hypothesis that amyloid-beta upregulates cerebral endothelial pannexin1 expression, which promotes vascular dysfunction and Alzheimer's disease progression through increased neuroinflammation and...
- The National Institute on Aging awarded Yale University $1.416 million on May 15, 2026, under the Aging Research program (CFDA 93.866) to investigate cell size inheritance and innate immune memory, with performance through April 30, 2031, in New Haven, Connecticut. The funded research examines how enlarged immune cells—specifically monocytes and mast cells—can maintain proliferative capacity and immune surveillance without transitioning into senescence, a hallmark of aging. The work centers on...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $298,419 to the Regents of the University of Michigan on February 1, 2026, under the Aging Research program (CFDA 93.866, Assistance Listing Project Grant R01AG097771). The recipient will develop advanced statistical and computational methods for analyzing immune cell data to enhance understanding of the immune system's role in aging and age-related diseases. The project addresses analytical...
- The National Institute on Aging awarded Yale University $544,318 under the Aging Research program (CFDA 93.866) on June 1, 2026, to conduct research on immunometabolic regulation of inflammaging by nerve-associated macrophages (NAMs). The project investigates how nerve-associated macrophages—a subset of macrophages residing on sympathetic nerve fibers—regulate the sympathetic nervous system and innate immune response to control chronic inflammation associated with aging. The research addresses...
The National Institute on Aging awarded Beth Israel Deaconess Medical Center, Inc. $518,555 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop spatially validated human lymphoid follicles-on-chip for modeling inflammaging and age-related immune dysfunction. The recipient will establish a lymphoid follicle organ-on-chip platform that recapitulates key hallmarks of human lymphoid function, including germinal center formation, AID expression, and antiviral antibody production. The work integrates high-content spatial profiling platforms with multiplex imaging and transcriptomic assays to model inflammaging by incorporating spatially profiled young and aged human lymphoid tissues. Preliminary data demonstrate that the platform supports viral replication and immune activation, resulting in increased follicle number and size, and that workflows are compatible with same-slide spatial multi-omics enabling integrated RNA and protein detection alongside spatial assays. The award is structured as a Project Grant with a period of performance from September 1, 2026, through August 31, 2028. Work is performed in Massachusetts. Beth Israel Deaconess Medical Center is a Harvard Medical School-affiliated nonprofit academic medical center in Boston, Massachusetts.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $518.6k | 8/20/26 |