Project Grant R21AG103487
- The National Institute on Aging, part of the National Institutes of Health, awarded $1,250,191 to the University of North Carolina at Chapel Hill on February 15, 2026, under the Aging Research program (CFDA 93.866) to develop an integrated artificial intelligence and experimental workflow for accelerating discovery of small-molecule modulators that influence Alzheimer's disease through microglial phagocytosis regulation. The funded work combines AI-driven computational methods with...
- The National Institute on Aging awarded $580,636 to North Carolina State University on January 15, 2026, under the Aging Research program (CFDA 93.866) to develop BOWID, a barcode system for lifelong tracking of individual Caenorhabditis elegans nematodes in aging studies. The project addresses a critical limitation in current aging research: population-level survival analysis obscures individual animal identity and prevents tracking of how early-life events shape aging trajectories and...
- The National Institute on Aging awarded the University of Pennsylvania $2,809,832 on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate epigenetic mechanisms driving cellular aging and age-associated disease. The award funds four integrated research projects examining chromatin homeostasis ("chromostasis") and senescence-associated secretory phenotype (SASP) in aging tissues. The research hypothesizes that age-related epigenetic changes result from...
- The National Institute on Aging awarded Yale University $461,311 under the Aging Research program (CFDA 93.866) on May 1, 2026, to investigate vascular smooth muscle cell aging and epigenetic reprogramming as a pathway to reducing cardiovascular disease risk. The research examines how smooth muscle cells in arterial walls undergo epigenetic alterations—particularly DNA methylation changes—that drive vascular stiffening and atherosclerosis in aging. Yale's team has developed smooth muscle...
- The National Institute on Aging awarded New York University $708,137 on February 1, 2026, under the Aging Research program (CFDA 93.866) to develop and validate technologies for probing the biophysical properties of aging cells. The funded work centers on developing genetically encoded multimeric particles (GEMs) as high-throughput microrheology probes to measure the physical properties of cell interiors—particularly within organelles including the nucleus, cytoplasm, endoplasmic reticulum,...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of North Carolina at Chapel Hill a $1,221,276 Project Grant (CFDA 93.866: Aging Research) on August 5, 2025, with a completion date of July 31, 2027. This award funds the development and application of Single-Cell Massively Parallel Reporter Assays (SCMPRA), a novel genomic platform designed to investigate how Alzheimer's disease (AD)-associated cis-regulatory elements (CREs) control gene expression across...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded Duke University $493,972 on January 1, 2026, under the Aging Research program (CFDA 93.866) to investigate cell type-specific epitranscriptomic regulation in the brain during aging and Alzheimer's disease. The research will determine how age-dependent differential methylation of adenosine (M6A) in distinct brain cell types influences the expression of genes associated with Alzheimer's disease. The...
- The National Institute on Aging awarded the University of Maryland, Baltimore $427,625 under Project Grant R21AG098680 on August 15, 2026, to develop machine learning regression tools that remove systematic prediction bias in aging clock calculations. Aging clocks estimate biological age from high-throughput multi-omics data and multimodal medical imaging, providing more accurate measures of age-related physiological functions than chronological age alone. Existing machine learning regression...
- The National Institute on Aging awarded New York University $705,405 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how changes in nuclear physical properties during cellular senescence drive transcriptional and splicing dysregulation characteristic of aging. The funded research measures nuclear biophysical properties across multiple length scales using a toolkit including genetically encoded multimeric nanoparticles (nucGEMS, 40–50 nanometers), newly...
- The National Institute on Aging awarded Duke University $1.597 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to support research on epitranscriptomic regulation of microglia in Alzheimer's disease. The research investigates how m6a methylation of adenosine residues in messenger RNA regulates microglial cell function and transitions between resting and activated states during Alzheimer's disease pathogenesis, with the goal of identifying novel...
The National Institute on Aging awarded the University of North Carolina at Chapel Hill $472,658 on August 15, 2026, under the Aging Research program (CFDA 93.866) to develop live-cell imaging tools that monitor biological age in real time based on age-associated DNA methylation changes. The project will engineer two classes of genetically encoded fluorescent sensors: a "ticking" global methylation epigenetic clock that continuously visualizes intranuclear 5-methylcytosine patterns, and an "alarm" locus-specific epigenetic clock that develops fluorescence only when methylation occurs at specific aging-associated loci. The recipient will quantify biological age by visualizing intranuclear DNA methylation patterns in live cells and develop a turn-on fluorescent sensor reporting DNA methylation at specific aging-associated loci. Machine learning-based pattern recognition will quantify aging trajectories and detect interventions that modulate cellular biological age. The tools will be validated in primary fibroblasts and induced pluripotent stem cells under various aging and rejuvenation conditions. Work is performed in Chapel Hill, North Carolina, with a period of performance extending through July 31, 2028. This is a Project Grant, an assistance type that supports biomedical, social, and behavioral research directed toward understanding aging processes and diseases affecting older adults.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $472.7k | 8/10/26 |