Project Grant R21AG085904
- Federal Grant Award Summary North Carolina State University received a $122,244 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded June 27, 2025, with completion targeted for January 31, 2027. The award funds research to decipher the function of cohesin and CTCF (CCCTC-binding factor) in r-loop-mediated DNA repair at telomeres. The project investigates how these protein complexes recognize DNA damage-induced r-loops—triple-stranded nucleic acid...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Washington University a Project Grant totaling $556,121 (awarded January 15, 2026, with completion by December 31, 2030) under the Aging Research program (CFDA 93.866) to conduct scientific research on transgenerational adaptation of longevity changes in response to repeated environmental stresses. The research investigates how organisms—specifically Caenorhabditis elegans—adapt across successive generations when...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of North Carolina at Chapel Hill a Project Grant of $647,866 under the Aging Research program (CFDA 93.866) on August 15, 2025, with a completion date of May 31, 2030. This award funds research investigating the epigenetic regulation of nuclear cyclic GMP-AMP synthase (cGAS) activity in aging-related inflammation. The research aims to elucidate the mechanisms by which histone H4 acetylation and its reader...
- Federal Grant Award Summary The Buck Institute for Research on Aging received $809,486 in Project Grant funding from the National Institute on Aging (CFDA 93.866 – Aging Research program) beginning February 1, 2026, through January 31, 2031. The award supports comprehensive biomedical research investigating the role of oxidation resistance 1 (OXR1) and retromer proteins in brain aging and Alzheimer's disease and related dementias (ADRD). The research leverages multiple model systems, including...
- Duke University received a $1,019,484.58 Project Grant award from the National Institutes of Health's National Institute on Aging under the Aging Research program (CFDA 93.866) for the period September 1, 2021 through May 31, 2022. The award will support research using the nematode C. elegans as a model organism to study aging-associated neurodegeneration at the molecular level, with the goals of uncovering novel mechanisms underlying this process and establishing C. elegans neurons as a...
- Federal Project Grant Award Summary The National Institute on Aging awarded the University of North Carolina at Chapel Hill a Project Grant totaling $675,157 (awarded August 20, 2025, with completion targeted for April 30, 2029) under the Aging Research program (CFDA 93.866) to conduct scientific research examining the interplay between biological aging and neuropsychiatric phenotypes following psychological trauma. The research will deliver integrated assessments combining molecular aging...
- Federal Project Grant Award Summary The National Institute on Aging awarded the University of Virginia a $522,167 Project Grant, effective August 1, 2025, through May 31, 2030, under the Aging Research program (CFDA 93.866). The award supports research investigating mechanisms of ribosomal DNA (rDNA) instability during aging, with the objective of understanding how genomic instability contributes to the aging process. The research focuses on characterizing the roles of the FOB1 protein and...
- Federal Project Grant Award Summary The University of North Carolina at Chapel Hill received a $1,221,276 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded August 5, 2025, with completion by July 31, 2027. This grant supports the development and application of single-cell massively parallel reporter assays (SCMPRA), an innovative research platform designed to investigate how Alzheimer's disease (AD)-associated cis-regulatory elements (CREs)...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $565,826 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective June 1, 2025 through May 31, 2030. The Baugh Lab will conduct fundamental research investigating how nutrient availability regulates developmental processes and gene expression using Caenorhabditis elegans (C. elegans) as a model...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded $506,000 in project grant funding to the Scripps Research Institute under the Aging Research program (CFDA 93.866) on August 15, 2025, with a completion date of July 31, 2027. The project, "Engineering Synthetic Biomolecular Condensates for Targeted Autophagy Modulation," will deliver foundational research and development of a novel biomolecular condensate (BMC)-based scientific tool designed to advance...
North Carolina State University received a $580,636 Project Grant award from the National Institute on Aging (Aging Research program, CFDA 93.866) effective January 15, 2026, through December 31, 2028. The award supports development of BOWID (Barcode of Worms Identification), a novel tracking system that enables lifelong identification and monitoring of individual Caenorhabditis elegans nematodes within population-based aging studies. The system uses stochastically labeled cellular landmarks created through the Cre-Lox recombination system to generate readable fluorescent protein barcodes unique to each organism, addressing a critical limitation in current aging research where individual animal identity is lost during standard survival analysis measurements. The project deliverables encompass three primary objectives: (1) development of robust BOWID components including inducible promoters, cellular landmarks, and machine learning pipelines for barcode detection; (2) implementation of BOWID for organisms cultured on traditional agar plates with subsequent aging trajectory analysis; and (3) adaptation and implementation of BOWID for animals cultured in microfluidic devices to examine structural aging in neurons. These technological innovations will enable researchers to trace individual aging trajectories, better understand how early-life events influence longevity rates, and analyze variability in lifespan outcomes across genetically identical populations exposed to identical conditions.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $580.6k | 1/9/26 |