Project Grant R21AG101308
- Federal Grant Award Summary Yale University received a $380,748 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 1, 2025, through May 31, 2028. This research initiative investigates the immunological mechanisms underlying exercise's beneficial effects on skeletal muscle aging. The project will deliver scientific research and analysis examining how mechanical stress-induced inflammation in muscle stromal cells and...
- Federal Project Grant Award Summary Yale University received a $681,277 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded May 15, 2026, with completion targeted for April 30, 2031. The research project, titled "Cell Size Inheritance and Innate Immune Memory," investigates the mechanisms by which immune cells enlarge without triggering senescence—a pathological state characterized by irreversible cell cycle arrest associated...
- Federal Grant Award Summary Yale University received a $746,160 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded on March 20, 2026, with a completion date of February 28, 2031. The research project, titled "Impact of Peripheral Inflammation on Microglia and Neurons in Aging," will be conducted at Yale's New Haven, Connecticut facility. This award supports biomedical research aimed at understanding the mechanisms by which...
- Federal Grant Award Summary Yale University received a $461,146 Project Grant from the National Institute on Aging (CFDA 93.866 – Aging Research program) awarded May 15, 2025, with a completion date of April 30, 2027. The award funds research targeting isoform-specific Fibroblast Growth Factor Receptor (FGFR) signaling in Idiopathic Pulmonary Fibrosis (IPF), a chronic progressive lung disease predominantly affecting adults over 65 years of age. The research addresses a significant clinical need,...
- Federal Project Grant Award Summary Yale University received a $461,146 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded on May 15, 2025, with completion targeted for April 30, 2027. The award funds research investigating the dysregulation of cortical astrocytes in Alzheimer's disease (AD) models. The primary deliverable is novel scientific research employing advanced mesoscopic imaging techniques to longitudinally measure...
- Federal Grant Award Summary Yale University received a $461,146 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded May 15, 2025, with completion targeted for April 30, 2027. The project, titled "Toward Developing a Navigation Model of the Aging Brain in the Marmoset," focuses on understanding the physiological function and organization of the entorhinal cortex (ERC) in marmosets to advance knowledge of Alzheimer's disease pathology...
- Federal Grant Award Summary Yale University received a $921,822 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded June 9, 2025, with completion targeted for May 31, 2027. The grant funds research investigating lysosomal regulation and functions of Tank-Binding Kinase 1 (TBK1) in neurodegenerative diseases, specifically amyotrophic lateral sclerosis and frontotemporal dementia. The research will deliver molecular and mechanistic insights...
- Federal Project Grant Award Summary Yale University received a $461,313 Project Grant award from the National Institute on Aging (Aging Research program, CFDA 93.866) effective June 1, 2025 through May 31, 2027. The grant supports research investigating the role of cysteine string protein alpha (CSPα) in presynaptic autophagy and its relationship to neurodegeneration. The project will generate scientific knowledge products including characterization of synaptic vesicles, autophagosomes, and...
- Federal Grant Award Summary The National Institute on Aging awarded the University of Pennsylvania a $2.8 million Project Grant under the Aging Research program (CFDA 93.866) for the five-year period from February 1, 2026, through January 31, 2031. The grant supports research on the epigenetics of aging and age-associated diseases, with particular focus on two mechanisms: chromostasis (homeostatic mechanisms that maintain dynamic chromatin stability) and the senescence-associated secretory...
- Federal Grant Award Summary Yale University received a $133,333 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 15, 2025, with completion targeted for August 31, 2026. The award funds research aimed at correcting the myeloid bias of aged hematopoietic stem and progenitor cells (HSPCs) by preventing linker histone turnover,...
Yale University received a $461,311 Project Grant from the National Institute on Aging (CFDA 93.866, Aging Research program) effective May 1, 2026 through April 30, 2028 to conduct research on vascular smooth muscle aging and the epigenetic clock. The research will investigate how epigenetic alterations, particularly DNA methylation changes, contribute to vascular smooth muscle cell (SMC) dysfunction and accelerated biological aging in the arterial wall—a key driver of cardiovascular disease in older adults. The project will deliver scientific knowledge and methodologies for assessing molecular and functional rejuvenation of aged SMCs through transient epigenetic reprogramming using pluripotency factors (OCT4, SOX2, KLF4, and C-MYC). The research will utilize novel SMC-specific epigenetic clocks developed by the research team using the Infinium Mouse Methylation Platform to evaluate whether transient epigenetic reprogramming can reverse hallmarks of SMC aging, preserve cell identity, and mitigate cardiovascular disease risk. The work will generate data, analytical tools, and foundational evidence supporting the potential for epigenetic interventions to address age-related vascular dysfunction. Deliverables will contribute to the National Institute on Aging's mission of supporting research to prevent and treat age-related diseases by advancing understanding of aging mechanisms at the cellular level.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $461.3k | 5/4/26 |