Project Grant R61AG094646
- The federal Project Grant award of $3,642,232.00, awarded on August 5, 2025 by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), aims to leverage genetics and multi-omic data to identify causal genes, cell types, and molecular mechanisms underlying Alzheimer's disease (AD). The project, titled "UNRAVELING THE GENETIC BASIS OF MOLECULAR FUNCTIONS IN ALZHEIMER'S DISEASE", will integrate multi-ancestry molecular quantitative trait loci (xQTL) data...
- This federal Project Grant award of $839,933 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate the role of N6-methyladenosine (m6A) RNA modifications in microglial dysfunction and Alzheimer's disease (AD) pathogenesis. The project aims to systematically map m6A modification landscapes in microglia isolated from human brain tissue and human induced pluripotent stem cell-derived microglial models. The researchers will also use CRISPR-based...
- This Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) provides $871,419 to the University of Washington to conduct research on the role of microglia, the brain's immune cells, in the pathogenesis of Alzheimer's disease. The research aims to characterize molecular profiles and spatial organization of microglia across the adult age spectrum, both with and without Alzheimer's disease, through single-nucleus RNA sequencing of over 5,000...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $848,286 to the University of South Florida to conduct research on the role of N6-methyladenosine (m6A) RNA modifications in Alzheimer's disease (AD). The key objectives are to: 1) Create a high-resolution map of m6A sites in the brains of older adults, 2) Identify specific m6A alterations associated with AD and its clinical/pathological features, and 3) Elucidate how m6A dysregulation may...
- This $2,151,878 federal Project Grant award, funded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), supports research at the University of North Carolina at Chapel Hill (UNC-CH) and its subrecipient, the University of Pennsylvania, to map the causal genetic-imaging-clinical pathway for Alzheimer's disease (AD). The key products and services to be delivered through this 3-year project include: Developing robust functional connectome analysis and causal...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to gain a mechanistic understanding of the role of cellular senescence in the pathogenesis of Alzheimer's disease (AD). The $460,625 grant will fund research at the University of Massachusetts Medical School to dissect the separate P53/P21 and P16 senescence pathways and their functional consequences in AD using human induced pluripotent stem cell-based models. The 2-year project will produce...
- This federal Project Grant award of $3,221,450.00 from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to define how neuronal hyperexcitability in the retrosplenial cortex (RSC) contributes to the development of Alzheimer's disease (AD)-related behavioral deficits in mouse models. The research aims to determine the effect of inhibiting RSC layer 5 cells on spatial memory and navigation, as well as when hyperexcitability emerges in these cells across different AD...
- This Project Grant award titled "Epitranscriptomic Regulation of Microglia in Alzheimer's Disease" was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to Duke University. The $509,413 grant, awarded on September 15, 2025, will support research to understand the role of epitranscriptomic regulation, specifically the m6A modification, in controlling microglial function and its contribution to Alzheimer's disease pathogenesis. The project aims to elucidate how...
- This federal Project Grant award for $528,876, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports research to investigate the cis- and trans-genetic regulation of brain transcriptomics and proteomics associated with Alzheimer's disease (AD) and AD-related dementias (ADRD). The key goals of the project are to: Estimate genome-wide cis- and trans-acting quantitative trait loci (QTLs) effects for transcriptome-wide genes and proteome-wide proteins across 4 brain...
- The University of North Carolina at Chapel Hill (UNC-CH) received a $427,625 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866) to develop and validate a computational framework for identifying excitation-inhibition imbalances in Alzheimer's disease (AD) using multi-modal neuroimaging data. The goal is to create an innovative technique that can noninvasively detect circuit-level disruptions in brain networks associated with AD pathology, which...
This $1,221,276 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports the "In Vivo Single-Cell Analysis of Alzheimer's Disease-Associated Regulatory Elements" research project at the University of North Carolina at Chapel Hill. The project aims to develop a novel genomic platform called Single-Cell Massively Parallel Reporter Assays (SCMPRA) to investigate how Alzheimer's disease-associated regulatory elements orchestrate gene expression across different cell types in the brain. The researchers will apply this platform to study mouse models of Alzheimer's disease, with the goal of identifying critical cell types and gene-environment interactions involved in the disease pathogenesis. The project period runs from August 5, 2025 to July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/11/25 | ||
| Not listed | $1.2m | 8/4/25 |