Project Grant R01AG089493
- Federal Project Grant Award Summary The University of Missouri System received a $429,394 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded December 15, 2025, with completion targeted for November 30, 2027. This research initiative addresses heart failure with preserved ejection fraction (HFpEF) in aging populations with comorbid conditions such as obesity and hypertension. The project focuses on investigating LARP6 (LA...
- Federal Grant Award Summary The University of South Florida received a $1,696,572 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 22, 2025, through May 31, 2030. This award supports transcriptome-wide mapping of the brain M6A (N6-methyladenosine) methylome in Alzheimer's disease. The research will generate three primary deliverables: (1) the first high-resolution reference map of M6A methylation sites across the...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $694,824 Project Grant to the University of California, San Francisco on August 1, 2025, under the Aging Research program (CFDA 93.866) to support a five-year research project extending through May 31, 2030. The award funds a scientific investigation titled "Triangulating Mechanisms of Microbiome-Joint Crosstalk," which examines the interorgan communication between the gut microbiome and joint tissues in the...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University a Project Grant totaling $1,851,569 under the Aging Research program (CFDA 93.866) for the period June 1, 2025, through March 31, 2030. This research initiative, titled "First In Last Out: How Development Informs Neurodegeneration," investigates the biological mechanisms linking early brain development to late-life Alzheimer's disease (AD) pathology. The project aims to empirically...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $412,500 Project Grant to the University of South Florida (USF) under the Aging Research program (CFDA 93.866) for a two-year research initiative running from June 1, 2025, through May 31, 2027. This grant funds scientific research aimed at identifying novel biomarkers for early diagnosis and prognosis prediction of Alzheimer's disease (AD), a neurodegenerative condition affecting 5.5 million Americans. The project...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $509,413 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 15, 2025 through May 31, 2030. This award funds scientific research investigating epitranscriptomic regulation of microglia in Alzheimer's disease (AD), with the primary deliverable being novel research findings and analysis concerning how adenosine methylation...
- Federal Project Grant Award Summary The University of Massachusetts Medical School received a $445,130 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective January 1, 2026 through December 31, 2030. This research project focuses on elucidating the mechanisms by which Membrane Spanning 4A (MS4A) genes regulate neurodegeneration in Alzheimer's disease and related neurodegenerative disorders, including frontotemporal dementia,...
- Federal Grant Award Summary The University of Missouri System received a $622,881 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective August 5, 2025, with a completion date of July 31, 2030. This research initiative investigates novel mechanisms of metabolic reprogramming in reactive astrocytes and brain repair following focal cerebral...
- Federal Grant Award Summary The University of California, San Francisco received a $805,573 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 15, 2025, with a completion date of June 30, 2030. This research initiative investigates the impact of N6-methyladenosine (M6A) RNA modifications in Alzheimer's disease and related tauopathies. The project will deliver comprehensive characterization of M6A-RNA changes and...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Trustees of Columbia University in the City of New York a $2,957,210 Project Grant under the Aging Research program (CFDA 93.866) on September 15, 2025, with a completion date of August 31, 2029. This award funds comprehensive biomedical research investigating the role of CD44 astrocytes in Alzheimer's disease (AD) pathophysiology. The research project will elucidate the functional mechanisms by which CD44 upregulation...
The University of Missouri System received a $676,608 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective February 1, 2026, with completion targeted for December 31, 2030. This translational research initiative investigates the role of the gut-brain axis in Alzheimer's disease (AD) mitigation through integrated human and preclinical animal studies. The project examines the correlation between gut microbiota dysbiosis and AD biomarkers (amyloid plaques, tau tangles, and neurodegeneration) using advanced 7-Tesla MRI neuroimaging, and evaluates therapeutic interventions including inducible nitric oxide synthase (iNOS) inhibition and inulin-based prebiotic dietary supplementation to potentially reverse disease progression and cognitive impairment. The research combines longitudinal human cohort analysis with fecal microbiome transplantation studies in triple transgenic AD mouse models to establish mechanistic links between dysbiosis and neuroinflammation, with the ultimate goal of identifying evidence-based interventions to mitigate AD risk and disease severity. This work aligns with the NIA's strategic mission to prevent and treat Alzheimer's disease and related dementias through biomedical research directed at understanding age-related neurodegenerative processes and developing novel therapeutic approaches for older adults.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $676.6k | 1/28/26 |