Project Grant R35GM158131

Award Date 8/1/25
Completion Date 6/30/30
Dollars Obligated $413K
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Columbia, MO 65211, USA
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This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $1,188,266 to the Icahn School of Medicine at Mount Sinai to conduct research on the regulation of the germ cell-to-maternal transition. The funded project aims to uncover how this critical developmental transition is regulated, focusing on understanding the changes in gene expression, targeting of germ cell-specific genes for...
The National Institute of General Medical Sciences (NIGMS) awarded a $508,315 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of California, San Diego (UCSD) to investigate the molecular mechanisms required for successful developmental progression from oocyte to embryo during a critical window of transcriptional silence in mammals. The overarching goal is to uncover post-transcriptional regulatory mechanisms, such as mRNA poly(A) tail dynamics, that...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $483,640 to The University of Texas Southwestern Medical Center to determine the roles of autophagy in gametogenesis in S. cerevisiae. The funded research aims to investigate three key areas: 1) how autophagy promotes gametogenesis, 2) how gametogenesis regulates autophagy, and 3) how stresses affect autophagy and...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $434,679 to Lehigh University from August 1, 2025 to July 31, 2030 to conduct research on nuclear envelope dynamics in meiotic quality control. The research aims to elucidate how the oocyte nuclear envelope integrates mechanical and chemical signals to regulate quality control in developing oocytes, with a focus on the...
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This Project Grant award, valued at $413,118.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports research to investigate organelle transport and organization during mammalian oogenesis, with a focus on understanding the mechanisms underlying primary oocyte determination, quiescence, and loss in adult ovaries. Key research objectives include:

  1. Defining the intercellular polarity and organelle transport patterns in mouse and human germline cysts to elucidate the process of primary oocyte determination.

  2. Identifying the functions of MACF1 and CAMSAP3 proteins in regulating intercellular polarity, organelle transport, and oocyte cell fate decisions.

  3. Characterizing the protein and organelle composition of the Balbiani body in mouse and human primary oocytes, and investigating its role in mediating oocyte quiescence, senescence, and cell death.

The research aims to advance the fundamental scientific understanding of mammalian oogenesis and its implications for women's health. The grant award period is from August 1, 2025 to June 30, 2030.

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