Project Grant R21AG098840
- This $6,026,530 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will fund a multi-year research project led by The Trustees of Columbia University in the City of New York. The project aims to investigate the causal role of particulate matter components in the development and progression of Lewy body dementia (LBD), a costly and debilitating...
- The National Institute on Aging (NIA) awarded a $400,707 Project Grant (CFDA 93.866 - Aging Research) to the University of Florida to map brain lipid architecture in aging, Lewy body dementia (LBD), and T-cell therapy. The 2-year grant, running from September 1, 2024 to August 31, 2026, will utilize novel imaging mass spectrometry to generate a spatial atlas of the lipidome and identify lipid markers of disease progression in LBD. The research aims to assess lipid alterations resulting from an...
- This $2,957,210 Project Grant was awarded by the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), to The Trustees of Columbia University in the City of New York (Health Sciences Division) on September 15, 2025. The grant supports a comprehensive research project titled "Deciphering the Role of CD44 Astrocytes in Alzheimer's Disease." The overarching objective is to elucidate the functional role of the CD44 protein in astrocytes and its...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $2,234,905.00 in funding to The University of Iowa to support research aimed at understanding the underlying mechanisms responsible for cognitive fluctuations in Lewy body disorders (LBD). The project will use mouse models to evaluate how the accumulation of...
- This $1,707,089 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research by Northwestern University to investigate synergistic approaches for enhancing endoplasmic reticulum (ER) proteostasis, protein trafficking, and lysosomal activity as potential treatments for dementia with Lewy bodies and Parkinson's disease-dementia. The research will use patient-derived induced pluripotent stem cell neuron models and mouse models to test the effects of...
- This $2,069,215 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research by Case Western Reserve University to investigate the role of the beta-arrestin2-LMBRD2 pathway in the transmission and toxicity of pathological alpha-synuclein, which is a defining hallmark of Lewy body diseases such as Parkinson's disease and dementia with Lewy bodies. The research will utilize cellular and animal models to study the mechanisms by which beta-arrestin2...
- This Project Grant award, valued at $475,377.00, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to The Trustees of Columbia University in the City of New York. The grant aims to determine the functional significance of microglial FOXO3, a key transcription factor, in Alzheimer's disease (AD) pathobiology. The research will investigate the role of FOXO3 in regulating lipid droplet accumulation and interferon-I pathway...
- This federal Project Grant award of $457,875.00 was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to the University of Connecticut Health Center. The grant funds the development and characterization of the first LRP10 knockout mouse model to investigate the role of LRP10 in the pathogenesis of Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies. The project aims to examine neuroinflammation, synaptic dysfunction,...
- This $461,146 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to investigate the disruption of astrocyte function and its relationship to cognitive decline in Alzheimer's disease (AD). The grant recipient, Yale University, will use novel imaging techniques to longitudinally track changes in astrocytic and neuromodulatory signaling across the cerebral cortex in genetic models of AD. The key objectives are to determine: 1) if early...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports scientific research to explore how striatal astrocytes, a type of glial cell, change with aging in mice. The $433,125 award, with a performance period from August 1, 2025 to July 31, 2027, will enable researchers at the University of California, Los Angeles to conduct molecular and cellular investigations of the striatum, a key brain region involved in motor function, to better understand how...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $452,375.00 to The Trustees of Columbia University in the City of New York to support research on the role of astrocyte glucocerebrosidase (GBA1) deficiency in exacerbating Lewy body dementia (LBD)-related pathology and cognitive impairment in a mouse model. The research aims to explore how GBA1 mutations contribute to the underlying pathophysiology of LBD, a leading cause of dementia after Alzheimer's disease. Specifically, the project will investigate how astrocyte GBA1 deficiency disrupts GABA transport and tonic inhibition, leading to increased neuronal excitability and more severe alpha-synuclein accumulation during the prodromal phase of LBD. The grant period runs from January 1, 2026 to December 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $452.4k | 12/23/25 |