Project Grant R21AG094032
Award Date
5/1/25
Completion Date
4/30/27
Dollars Obligated
$458K
Federal Agency
National Institute on Aging
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Farmington, CT 06030, USA
Similar Awards
The National Institute on Aging (NIA) awarded a $190,625 Project Grant (CFDA 93.866 - Aging Research) to the University of Florida to conduct research on the DNAJC13 P.N860S genetic mutation and its role in Parkinson's disease (PD) pathogenesis. The goal is to further characterize the DNAJC13 P.N860S knock-in (DKIHET) mouse model, examining its impact on alpha-synuclein biology, dopaminergic function, and neuroinflammation. Key research activities include analyzing protein-binding in striatal...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $1,641,495 will fund research at the University of Florida to investigate the molecular mechanisms by which mutations in the GBA1 gene influence the development of Lewy Body Dementia (LBD). The project will use induced pluripotent stem cell-derived neurons, both wildtype and with pathogenic GBA1 mutations, to examine how GBA1 impacts the regulation, trafficking, and maturation of key lysosomal...
The National Institute on Aging (NIA) awarded a $655,638 Project Grant under the Aging Research Federal Grant Program (CFDA 93.866) to the University of Denver. The grant, which runs from September 2024 to February 2027, will support research to develop synthetic protein mimetics as potential therapeutics for Lewy Body Dementia (LBD). The project aims to optimize the pharmaceutical properties and efficacy of these synthetic protein mimetics in inhibiting alpha-synuclein aggregation and...
This $1,707,089 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) supports a research project led by Northwestern University. The project aims to synergistically enhance endoplasmic reticulum (ER) proteostasis, protein trafficking, and lysosomal activity as potential treatments for dementia with Lewy bodies (DLB) and Parkinson's disease-dementia (PDD). The researchers will use patient-derived induced pluripotent stem cell neuron models and mouse...
This $2,253,665 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate the pathomechanisms of apolipoprotein E4 (APOE4), a major genetic risk factor for Lewy body dementia (LBD), and its influence on alpha-synuclein pathology. The primary research objectives are to: 1) conduct multi-omics profiling of human LBD brains to uncover lipid and endosomal-lysosomal dysfunction associated with APOE4, 2) use astrocyte-specific APOE3 or APOE4...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides funding of $692,401 to Brigham & Women's Hospital Inc. from June 1, 2024 to May 31, 2029 to conduct research on the mechanistic dissection of lipase (LIPE) regulation of fatty acid homeostasis as a potential therapeutic strategy for Parkinson's disease (PD), Lewy body dementia (LBD), and other synucleinopathies. The research aims to: 1) Investigate the interplay between alpha-synuclein and...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides funding of $136,032 to The Jackson Laboratory in Bar Harbor, Maine. The award supports research to investigate the role of the gene LRFN2 as a potential resilience factor against cortical neurodegeneration associated with Alzheimer's disease (AD). The project aims to develop a novel LRFN2 overexpression mouse model and evaluate its impact on AD-related cortical neurodegeneration,...
The National Institute on Aging (NIA) awarded a $2,069,215 Project Grant (CFDA 93.866) to Case Western Reserve University (CWRU) to investigate the role of the beta-arrestin2-LMBRD2 cascade in the pathogenesis of alpha-synuclein, a key protein involved in Lewy body diseases like Parkinson's disease and dementia with Lewy bodies. The research aims to elucidate the mechanisms governing the internalization and transmission of pathological alpha-synuclein, which is critical for understanding disease...
This federal Project Grant award from the National Institute on Aging (NIA) under CFDA Program 93.866 (Aging Research) supports research to investigate neural circuit dysfunction in the lateral entorhinal cortex (LEC) of an Alzheimer's disease (AD) mouse model. The $1,566,554 grant awarded to the University of California, Irvine aims to determine: 1) the cell types exhibiting activity dysfunction in the LEC, 2) whether LEC dopamine dysfunction causes memory impairment, and 3) if LEC...
This Project Grant award in the amount of $640,895.00, titled "A MOUSE MODEL FOR BRAAK I/II ALZHEIMER'S PATHOLOGY", was provided by the National Institute on Aging under the Aging Research Federal Grant Program (CFDA 93.866). The goal of this study is to characterize a novel mouse mutant with a phenotype resembling Braak stage I/II Alzheimer's disease (AD) pathology and to develop this line into a novel animal model for AD research. Specifically, the project will: 1) Determine the...