Project Grant RF1NS144268
- This $3,264,260 Project Grant award from the National Institute on Aging (NIA) under CFDA 93.866 (Aging Research) aims to determine whether olfactory impairment caused by exposure to ambient fine particulate matter (PM2.5) pollution is a causal factor in the development of late-onset dementia, including Alzheimer's disease. The award will fund a comprehensive research project conducted by the University of Maryland, Baltimore to investigate the role of the cGAS/STING/IKK2/NF-κB inflammatory...
- This $3,145,300 federal Project Grant award was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to investigate how the ubiquitin-proteasome system (UPS), specifically the proteasome complexes, are affected in Alzheimer's disease (AD), progressive supranuclear palsy (PSP), and Parkinson's disease. The research aims to elucidate the regulation of the proteasome complex, a key component of protein homeostasis, and its potential role in the pathogenesis of...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $732,992 to Virginia Commonwealth University to elucidate the role of cholinergic degeneration in cognitive fluctuations (CF) in Lewy body dementia (LBD). The project aims to determine the association between cholinergic degeneration and CF in LBD, using neuroimaging techniques...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $231,000 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Rochester. The grant, which runs from March 1, 2025 to January 31, 2028, aims to develop culturally-tailored approaches to improve equity in palliative care research and service delivery for individuals with Parkinson's disease, Lewy body dementia, and related disorders living...
- This $2,069,215 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research by Case Western Reserve University to investigate the role of the beta-arrestin2-LMBRD2 pathway in the transmission and toxicity of pathological alpha-synuclein, which is a defining hallmark of Lewy body diseases such as Parkinson's disease and dementia with Lewy bodies. The research will utilize cellular and animal models to study the mechanisms by which beta-arrestin2...
- This three-year, $4.766 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, aims to clarify the neuropathological, molecular, and genetic differences between Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB) through the Aging Research grant program (CFDA 93.866). The J. David Gladstone Institutes will use digital pathology, artificial intelligence, single-nuclei RNA sequencing, and spatial transcriptomics on...
- This $1,707,089 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research by Northwestern University to investigate synergistic approaches for enhancing endoplasmic reticulum (ER) proteostasis, protein trafficking, and lysosomal activity as potential treatments for dementia with Lewy bodies and Parkinson's disease-dementia. The research will use patient-derived induced pluripotent stem cell neuron models and mouse models to test the effects of...
- The National Institute on Aging (NIA) awarded a $2,151,314 Project Grant to the University of Missouri System under the Aging Research program (CFDA 93.866) to conduct research on the effects of fine particulate matter (PM) exposure on small cerebrovascular inflammation and cognitive dysfunction. The 3-year project aims to investigate how PM exposure induces sex-specific inflammatory responses mediated by TNF-alpha in males and IL-6 in females, leading to cognitive impairment. The research...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $1,625,947 to the University of Rochester to conduct research on the relationship between air pollution-derived iron exposure, poverty-related stress, and Alzheimer's disease risk. The key objectives are to evaluate whether ambient and subway-level iron exposure leads to...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to identify changes in synaptic vesicle-binding of alpha-synuclein as an early biomarker for Parkinson's disease (PD) and Alzheimer's disease related dementias (ADRD). The $793,535 award, with a project period from December 1, 2024 to November 30, 2029, will fund studies...
This $3,013,265 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA Program 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders will fund a research study to investigate the causal role of particulate matter components on Lewy body dementia. The award was granted to The Trustees of Columbia University in the City of New York, who will utilize large-scale epidemiological data, advanced statistical methods, and mechanistic animal studies to identify which specific components of fine particulate matter (PM2.5) are associated with Lewy body dementia diagnoses and how they promote alpha-synuclein aggregation and prion-like spreading. This multidisciplinary research project aims to improve understanding of environmental factors that may contribute to the development and progression of Lewy body dementia, a growing public health issue affecting 1.4 million individuals in the United States.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.0m | 7/30/25 |