Project Grant R21AG102427
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the development and evaluation of a 3D engineered muscle tissue model to study the metabolic response to muscle contraction in the context of aging. The University of Washington, a prominent research institution, will lead this 2-year project to: 1) examine the mitochondrial mechanisms underlying the decreased metabolic response to muscle contraction in aged human 3D engineered...
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at the University of Washington to investigate genomic alterations in skeletal muscle associated with aging. The key objectives are to: Explore if alternative splicing of mRNA results in quantitative differential isoform changes associated with aging, potentially leading to increased expression of non-functional proteins relevant for healthy muscle function. The researchers...
- The National Institute on Aging awarded The Washington University $427,625 on February 15, 2026, under the Aging Research program (CFDA 93.866) to investigate intramuscular adipose tissue quality and its relationship to muscle weakness in aging. The research addresses the mechanism by which ectopic adipose tissue accumulates within muscle boundaries during aging, impairing muscle contraction through secreted signals. The project tests the hypothesis that intramuscular adipose tissue quality...
- The National Institute on Aging awarded the University of Wisconsin System $698,690 on February 1, 2026, under the Aging Research program (CFDA 93.866) to conduct research on the molecular mechanisms of fiber type-specific skeletal muscle dysfunction with aging. The research quantifies proteome changes associated with fiber type-specific atrophy in older males and females, determines cross-bridge mechanisms for fiber type-specific impairments in contractile function, and identifies fiber...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Johns Hopkins University $427,625 for Project Grant R21AG102518 on September 1, 2026, under the Aging Research program (CFDA 93.866). The recipient will develop a human three-dimensional neuromuscular microphysiological system to model skeletal muscle aging ex vivo. The platform integrates primary human muscle stem cells from young (20–30 years) and aged (60–75 years) donors, induced pluripotent...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $533,500 to the Buck Institute for Research on Aging on July 15, 2026, under the Aging Research program (CFDA 93.866). The award funds examination of the role of autonomic innervation in muscle stem cell aging. The research investigates the functional link between autonomic nervous system neurons and muscle stem cells using Drosophila melanogaster as a model organism. The project will refine...
- The National Institute on Aging awarded New York University $466,125 under the Aging Research program (CFDA 93.866) on January 15, 2026, to develop innovative magnetic resonance imaging analysis tools for identifying microstructural biomarkers of skeletal muscle health across the lifespan. The project, titled "(Micro)structural Biomarkers of Skeletal Muscle Health Across the Lifespan," addresses sarcopenia—a leading cause of disability and mortality in aging populations—by creating...
- The National Institute on Aging awarded the University of Florida $540,345 on September 1, 2026, under the Aging Research program (CFDA 93.866) to support research into a metabolic sensor-driven metabolite repair system that maintains muscle stem cell homeostasis. The research addresses loss of skeletal muscle stem cell function as a central driver of impaired regeneration, progressive muscle wasting, and frailty in aging, muscular dystrophies, and metabolic diseases. The project investigates...
- The National Institute on Aging awarded the University of Washington $777,500 on September 15, 2025, under the Aging Research program (CFDA 93.866) to conduct quantitative and qualitative research on interfacility transfers of older adults from emergency departments to other hospitals. The project will characterize outcomes and adverse events among transferred older adults using statewide administrative claims data, explore the experiences of older adults and care partners during transfer, and...
- The National Institute on Aging, within the Department of Health and Human Services, awarded $434,856 to the University of Nebraska Board of Regents on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of microRNAs in sarcopenia through a novel muscle-specific mouse model. The recipient will test the hypothesis that microRNA dysregulation contributes to age-related muscle loss by pursuing two specific aims: blocking microRNA-mediated gene repression to...
The National Institute on Aging awarded the University of Washington $485,375 under the Aging Research program (CFDA 93.866) on September 1, 2026 for Project Grant R21AG102427. The award funds development and expansion of naturally aged three-dimensional engineered muscle tissue (3D-EMT) models to test metabolic and contractile function in vitro as a mechanistic platform for studying sarcopenia. The research examines the contribution of extracellular factors to aged 3D-EMT function and characterizes the impact of co-culture conditions on muscle tissue performance, building on prior collaboration with the Study of Muscle, Mobility and Aging (R01 AG059416). The University of Washington's research team comprises experts in tissue engineering, metabolic function, and muscle mechanics, and will leverage the institution's Institute for Stem Cells and Regenerative Medicine, Center for Translational Muscle Research, and Nathan Shock Center of Excellence in the Basic Biology of Aging. The award covers the period of September 1, 2026 through August 31, 2028. Work is performed in Seattle, Washington. The University of Washington Office of Sponsored Programs receives the award and administers the grant through its Grant & Contracts Division.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/27/26 | ||
| Not listed | $485.4k | 8/21/26 |