Project Grant R21AG095657
- This Project Grant award of $506,404.00 was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to investigate mechanisms of local and global epigenetic changes that drive senescence and aging-associated phenotypes. Key research objectives include: Examining how enhancers are rewired during senescence and aging, focusing on large enhancer communities or "cliques" and identifying transcription factors that drive their formation....
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to gain a mechanistic understanding of the role of cellular senescence in the pathogenesis of Alzheimer's disease (AD). The $460,625 grant will fund research at the University of Massachusetts Medical School to dissect the separate P53/P21 and P16 senescence pathways and their functional consequences in AD using human induced pluripotent stem cell-based models. The 2-year project will produce...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $126,956.00 to the University of California, San Diego (UCSD) to conduct research on identifying mechanisms of adult neurogenesis in the aging brain. The key objectives of this project are to: Utilize single cell spatial transcriptomics to define the pathways of generating new neurons in aged neurogenic niches following transient, antisense oligonucleotide-mediated suppression of the PTBP1...
- This Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund research into the molecular interplay of sleep and neurodegeneration using the Drosophila model system. With $2.14 million provided over 11 months, the Trustees of the University of Pennsylvania will investigate how expression of the TDP-43 protein linked to neurodegenerative diseases disrupts sleep in fruit flies. Researchers will aim to define the specific glial subtypes...
- The National Institutes of Health's National Institute on Aging awarded $256,331.40 under the Aging Research program (CFDA 93.866) to The Trustees of the University of Pennsylvania from February to October 2021. The project aims to develop novel machine learning algorithms and biomedical software to more accurately quantify brain aging and predict the onset of neurodegenerative diseases such as Alzheimer's. Specifically, the funding will support refining predictive models of the...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $159,492 to Weill Medical College of Cornell University to support research focused on identifying and characterizing clonal expansions in aging and aging-related diseases. The key products/services to be delivered under this award include: Developing tools to enable the identification of candidate somatic variants at scale from publicly available data using machine learning approaches. Applying...
- This federal Project Grant award of $2,586,818.00 was provided by the National Institute on Aging under the Aging Research program (CFDA 93.866) to the Fred Hutchinson Cancer Center in Seattle, Washington. The grant aims to elucidate the mechanisms of communication between adipocytes (fat cells) and the brain, and their impact on glial cell function, neuroprotection, and brain aging. The research will focus on investigating how adipocyte-derived lipoproteins and mitochondrial signals influence...
- This $209,148 federal Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) aims to develop the first lifespan-matched, comparative single-cell spatial transcriptomic atlas of the prefrontal cortex and hippocampus in humans and rhesus macaques. Using the cutting-edge Spatial Molecular Imager (SMI) platform, the project will generate high-resolution, single-cell gene expression profiles across different life stages - young, adult, and aged -...
- This $1,081,439 federal Project Grant award from the National Science Foundation's Biological Sciences Program (CFDA 47.074) supports research to uncover the biochemical mechanisms behind cellular aging. The project, titled "TRACING THE COORDINATED CONTROL OF NAD+ HOMEOSTASIS", aims to create a comprehensive database and metabolic map of NAD+ biology throughout the lifespan. This research will investigate how NAD+ metabolism is maintained, regulated, and disrupted as cells age, with...
- The Pennsylvania State University was awarded a $388,648 Project Grant from the National Institute on Aging (CFDA 93.866 - Aging Research) to conduct research on how Polycomb Repressive Complexes (PRC1) regulate chromatin environments and maintain cellular transcriptomes during brain aging. The research aims to identify PRC1 composition and chromatin modifications across various brain cell types in young and aged mice, leveraging the university's recently developed biotinylation-mediated...
This Project Grant award for $446,875 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to gain genetic insights into cellular senescence using the Drosophila (fruit fly) brain. The project aims to leverage the powerful genetics of Drosophila to identify key drivers of senescence in neurons and glia, with the goal of modulating senescence onset and mitigating associated age-related brain decline. The award is held by the Trustees of the University of Pennsylvania, a leading academic research institution, and the project period runs from September 2025 to August 2027. The research will involve screening approaches to uncover genetic factors that can either accelerate or mitigate senescence, with a focus on understanding the role of mitochondrial decline in triggering this process. Insights from this project could inform strategies for manipulating senescence to promote healthy aging and address neurodegenerative conditions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $446.9k | 8/5/25 |