Project Grant 2441332
- The National Science Foundation awarded a $138,000 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to support research titled "A Novel Model System for Studying the Evolution and Genomics of Longevity" from July 1, 2021 to June 30, 2023. The two-year award will fund the development of a new model organism to advance understanding of longevity through the study of evolution and genomics. The Biological Sciences program aims to promote progress in the...
- This $522,167 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research into the "Mechanisms of rDNA Instability During Aging" at the University of Virginia. The project will investigate the role of the FOB1 protein and the RNA Polymerase I transcription factor UAF in regulating double-strand breaks and recombination at the ribosomal DNA locus, a key driver of genomic instability and aging. The research will utilize innovative techniques...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,208,503.00 to Cornell University to conduct research on the role of autophagy in cellular aging. The project, titled "System-wide and Mechanistic Deconvolution of Autophagy in Cellular Aging", aims to systematically investigate how different forms of autophagy influence cellular aging processes, with a focus on understanding how modulating selective autophagy pathways such...
- This Project Grant award of $506,404.00 was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to investigate mechanisms of local and global epigenetic changes that drive senescence and aging-associated phenotypes. Key research objectives include: Examining how enhancers are rewired during senescence and aging, focusing on large enhancer communities or "cliques" and identifying transcription factors that drive their formation....
- This National Science Foundation (NSF) Project Grant, funded under the Biological Sciences program (CFDA 47.074), supports collaborative research at North Dakota State University (NDSU) to mechanistically examine aging dynamics across insect life stages and tissues. The $614,175 award from August 1, 2023 to July 31, 2026 will investigate how insect metamorphosis and overwintering dormancy (diapause) influence cellular senescence and organismal lifespan. The research aims to provide new...
- This federal Project Grant award for $1,249,147.00 was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The grant is a collaborative effort between Epicypher, Inc., a biotechnology company in Durham, North Carolina, and Dr. Nicolas Young of Baylor College of Medicine to develop a novel platform called AgingPTM for studying aging-associated combinatorial histone post-translational modifications (ACPTMs) in tissue. This platform is intended to...
- This federal Project Grant award of $438,625.00 from the National Institute on Aging (CFDA 93.866 Aging Research) to Brown University aims to study how the cellular senescence phenotype changes over time and develop technology to track the duration of cells in senescent states. The key objectives are to (1) examine how the senescence phenotype, including the senescence-associated secretory phenotype (SASP), evolves from early to deeper states, and (2) advance a multi-symbol molecular recorder...
- This $1,031,595 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The awardee, Dana-Farber Cancer Institute, will define the landscape and mechanisms of protein redox regulation during aging. Specifically, the Institute will systematically map cysteine oxidation networks in mouse tissues to determine their role in coordinating protein complex assemblies relevant to age-related...
- This Project Grant award for $446,875 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to gain genetic insights into cellular senescence using the Drosophila (fruit fly) brain. The project aims to leverage the powerful genetics of Drosophila to identify key drivers of senescence in neurons and glia, with the goal of modulating senescence onset and mitigating associated age-related brain decline. The award is held by the Trustees of the University of...
- This Project Grant award of $387,006 from the National Institute on Aging (NIA) under CFDA Program 93.866 - Aging Research supports research to understand how indoles derived from commensal gut bacteria can promote mobility and counteract sarcopenia (age-related muscle wasting) in aging animals. The research aims to determine the mechanisms by which indoles regulate muscle protein homeostasis, mitochondrial function, and other cellular pathways to maintain muscle mass and function during...
This $1,081,439 federal Project Grant award from the National Science Foundation's Biological Sciences Program (CFDA 47.074) supports research to uncover the biochemical mechanisms behind cellular aging. The project, titled "TRACING THE COORDINATED CONTROL OF NAD+ HOMEOSTASIS", aims to create a comprehensive database and metabolic map of NAD+ biology throughout the lifespan. This research will investigate how NAD+ metabolism is maintained, regulated, and disrupted as cells age, with potential implications for understanding the basis of aging and age-related diseases. In addition to advancing scientific knowledge, the project will involve undergraduates in meaningful research and include an annual science outreach workshop in rural Mississippi. The grant has an award date of August 1, 2025 and an ultimate completion date of July 31, 2030. The research will be conducted by the Pennsylvania State University, a prominent federal contractor and grantee.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.1m | 7/29/25 |