Project Grant R21AG095562
- This Project Grant award of $506,404.00 was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to investigate mechanisms of local and global epigenetic changes that drive senescence and aging-associated phenotypes. Key research objectives include: Examining how enhancers are rewired during senescence and aging, focusing on large enhancer communities or "cliques" and identifying transcription factors that drive their formation....
- This Project Grant award for $446,875 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to gain genetic insights into cellular senescence using the Drosophila (fruit fly) brain. The project aims to leverage the powerful genetics of Drosophila to identify key drivers of senescence in neurons and glia, with the goal of modulating senescence onset and mitigating associated age-related brain decline. The award is held by the Trustees of the University of...
- The National Institutes of Health's National Institute on Aging awarded $256,331.40 under the Aging Research program (CFDA 93.866) to The Trustees of the University of Pennsylvania from February to October 2021. The project aims to develop novel machine learning algorithms and biomedical software to more accurately quantify brain aging and predict the onset of neurodegenerative diseases such as Alzheimer's. Specifically, the funding will support refining predictive models of the...
- This $1,081,439 federal Project Grant award from the National Science Foundation's Biological Sciences Program (CFDA 47.074) supports research to uncover the biochemical mechanisms behind cellular aging. The project, titled "TRACING THE COORDINATED CONTROL OF NAD+ HOMEOSTASIS", aims to create a comprehensive database and metabolic map of NAD+ biology throughout the lifespan. This research will investigate how NAD+ metabolism is maintained, regulated, and disrupted as cells age, with...
- The University of Pittsburgh was awarded a $794,978 Project Grant from the National Institute on Aging (CFDA 93.866 - Aging Research) to conduct research on the mechanisms by which socioeconomic disadvantage across the lifespan impacts cognitive function and decline in midlife. The research will longitudinally examine accelerated epigenetic aging as a biological mechanism connecting individual and community-level socioeconomic disadvantage to poorer cognitive function and greater cognitive...
- This federal Project Grant award of $2,358,537.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a research project titled "Epigenetic Aging, Cognitive Function and Exercise in Older Adults" at the University of Pittsburgh. The project aims to investigate the impact of exercise on epigenetic aging and its relationship to cognitive function, brain health, and Alzheimer's disease biomarkers in non-cognitively impaired older adults. The award period runs from...
- This federal Project Grant award of $429,338, provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), will support research to examine the neuroprotective role of the RNA binding protein RBM8A in Alzheimer's disease (AD) and related dementias. The primary objective is to investigate how different gene dosages of RBM8A affect pathological and behavioral changes in a 5XFAD mouse model of AD, and to identify the key targets responsible for RBM8A-dependent...
- This $1,221,276 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports the "In Vivo Single-Cell Analysis of Alzheimer's Disease-Associated Regulatory Elements" research project at the University of North Carolina at Chapel Hill. The project aims to develop a novel genomic platform called Single-Cell Massively Parallel Reporter Assays (SCMPRA) to investigate how Alzheimer's disease-associated regulatory elements orchestrate gene expression...
- This National Science Foundation (NSF) Project Grant award under the Social, Behavioral, and Economic Sciences (CFDA 47.075) program provides $394,032 to The Pennsylvania State University (Penn State) to advance research on using epigenetic age estimation methods for archaeological and forensic applications. The project aims to: (1) develop a cost-efficient, degradation-resistant genomic methylation typing method; (2) create a high-quality predictive model of age from bone methylation signals;...
- This Project Grant award of $147,486 was provided by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training federal grant program (CFDA 93.859), to The Trustees of the University of Pennsylvania for the period of January 1, 2025 to June 30, 2026. The goal of this research project is to investigate the distinct molecular roles of Polycomb Repressive Complexes 1 and 2 (PRC1 and PRC2) and upstream factors in establishing silencing at...
The Pennsylvania State University was awarded a $388,648 Project Grant from the National Institute on Aging (CFDA 93.866 - Aging Research) to conduct research on how Polycomb Repressive Complexes (PRC1) regulate chromatin environments and maintain cellular transcriptomes during brain aging. The research aims to identify PRC1 composition and chromatin modifications across various brain cell types in young and aged mice, leveraging the university's recently developed biotinylation-mediated lineage-specific capture (BLINC) technique. This 2-year project, running from September 1, 2025 to August 31, 2027, seeks to elucidate the role of PRC1 in regulating epigenetic changes and gene expression during the aging process, with the ultimate goal of enhancing understanding of cellular mechanisms underlying brain aging and age-related cognitive decline.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $388.6k | 8/18/25 |