Project Grant R21AG095656
- Federal Project Grant Award Summary The University of Pittsburgh received a $190,088 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective July 1, 2026, through March 31, 2031. This K23 career development award funds a five-year research initiative to investigate the relationship between sedentary behavior and Alzheimer's disease (AD) risk. The research will deliver comprehensive scientific analysis examining how sedentary behavior...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $2.003 million Project Grant to the University of Pittsburgh under the Aging Research program (CFDA 93.866) on September 15, 2025, with a completion date of August 31, 2029. This award funds research to characterize white matter injury in Alzheimer's disease (AD) and its role in cognitive decline. The study employs a novel, spatially precise neuroimaging methodology called Unhealthy White Matter Connectivity (UWMC) to...
- Federal Grant Award Summary The University of Pittsburgh received a $3.1 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 1, 2025, through August 31, 2029. This award supports biomedical research investigating the mechanistic relationship between persistent DNA damage-induced immune responses and aging. Specifically, the research examines how the cGAS-STING (cyclic GMP-AMP synthase–stimulator of interferon genes)...
- Federal Project Grant Award Summary The University of Pittsburgh received a $664,619 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective January 1, 2026 through December 31, 2030, to develop multiscale computational and experimental models of neurometabolic coupling across the lifespan. The project delivers research outputs addressing the critical gap in understanding metabolic dysfunction in late-onset Alzheimer's disease (AD)...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded $424,913 to the University of Pittsburgh under the Aging Research program (CFDA 93.866) effective July 1, 2026, through June 30, 2028. This exploratory R21 Project Grant funds research to characterize LAMP5+ interneurons—a specialized subset of brain cells—within the human entorhinal cortex (EC), a region critical to memory function where Alzheimer's disease (AD) pathology appears earliest. The project deliverables...
- Summary of Federal Project Grant Award The University of Pittsburgh received a $453,785 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) effective May 1, 2026 through April 30, 2028. This exploratory research award funds investigation into the cross-species roles of the TCER-1/TCERG1 protein in fertility and reproductive aging. The project delivers scientific research outputs examining whether the mammalian transcription elongation and splicing...
- Federal Project Grant Award Summary Emory University received a $627,646 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded February 15, 2026, with completion targeted for January 31, 2031. The award funds a randomized controlled trial testing the efficacy of REPAIR Sleep, a five-week cognitive behavioral therapy for insomnia (CBT-I) intervention delivered via videoconferencing to dyads consisting of persons living with dementia and...
- Federal Grant Award Summary The University of Pittsburgh received a $2.48 million Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded September 15, 2025, with a completion date of August 31, 2029. The award supports basic biomedical research investigating the molecular mechanisms underlying benign prostatic hyperplasia (BPH) and lower urinary tract...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of Pittsburgh $428,123 under the Aging Research program (CFDA 93.866) for a project titled "Suppressing Aging-Associated Increase of GATA4 Levels to Rejuvenate Old Chondrocytes." The award, effective February 1, 2026, through January 31, 2028, funds biomedical research directed at understanding and reversing age-related deterioration in chondrocytes—the primary cell type in articular...
- Federal Grant Award Summary The National Institute on Aging awarded a $162,200 Project Grant to The Research Foundation for the State University of New York (doing business as SUNY Downstate Health Sciences University) under the Aging Research program (CFDA 93.866). The award, issued August 15, 2025, with a completion date of July 31, 2027, supports a pilot research study investigating vasopressin 2 receptor (V2R) expression and function in the bladder across different age groups and...
The University of Pittsburgh received a $437,250 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), with an award date of July 15, 2026 and completion date of June 30, 2028. The grant funds the ANOWSM (Addressing Nocturia in Older Women Utilizing Behavioral Sleep Intervention and Brief Mindfulness) Study, a clinical research initiative designed to develop and evaluate behavioral interventions for nocturia—nighttime urination—in women aged 65 and older. The research deliverables include testing the efficacy and acceptability of Brief Behavioral Treatment of Insomnia (BBTI), Brief Mindfulness (MI) interventions, and combined approaches across a 60-subject randomized controlled trial, with assessment endpoints at treatment completion (week 4), 3-month follow-up, and 6-month follow-up. The primary products of this award are clinical research findings examining how BBTI and MI interventions independently and in combination reduce nocturia symptoms and nocturnal polyuria (increased nighttime urine production). The research addresses a significant public health burden—nocturia costs an estimated $83 billion annually and increases risks of falls, fractures, depression, and nursing home placement among older adults. By shifting focus from traditional bladder-focused treatments to sleep-centered behavioral approaches, the study aims to generate evidence supporting scalable, efficient interventions with improved patient compliance and lower implementation burdens than existing therapies.Federal Project Grant Award Summary