Project Grant R21AG093262
- This $1,031,595 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The awardee, Dana-Farber Cancer Institute, will define the landscape and mechanisms of protein redox regulation during aging. Specifically, the Institute will systematically map cysteine oxidation networks in mouse tissues to determine their role in coordinating protein complex assemblies relevant to age-related...
- This $412,751 Project Grant, awarded on August 15, 2024 by the National Institute on Aging (CFDA 93.866 - Aging Research), will fund research by The Trustees of Columbia University in the City of New York to study protein turnover alterations in the aging brain. The project aims to: (I) study the stoichiometry of the ribosome and proteasome; (II) measure changes in protein complex composition; (III) reveal how aging affects protein interaction state turnover; and (IV) address the effects of...
- This $147,486 Project Grant awarded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) supports research to investigate the role of chaperone-mediated autophagy (CMA) in cellular senescence and its contribution to aging. The research aims to understand: 1) if CMA activity changes upon induction of senescence, 2) if CMA modulates senescence kinetics and by what mechanism(s), 3) if CMA is required for senescent cell clearance, and 4) if restoring CMA activity...
- This Project Grant award of $125,901 from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to determine the role of alternative polyadenylation (APA) in neurodegenerative diseases like Alzheimer's and Parkinson's. The primary awardee, President and Fellows of Harvard College (doing business as Harvard Medical School), will repurpose 3'-biased single-nucleus RNA-sequencing data from over 350 post-mortem human brain samples to map APA at the single-cell level in these...
- This federal Project Grant award of $122,858.00 was provided by the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), to Harvard T.H. Chan School of Public Health. The project aims to utilize plasma metabolomic and proteomic profiling to investigate the relationship between genes, proteins, metabolites, and mortality risk. Specifically, the grant will fund research to determine genetic factors that influence a plasma metabolomic signature previously...
- The National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, awarded a $461,313 Project Grant under the Aging Research federal grant program (CFDA 93.866) to Yale University. The funding supports a 2-year research project to investigate the role of the protein CSPalpha in regulating presynaptic autophagy and neurodegeneration. Key objectives include characterizing synaptic vesicles and autophagosomes in wild-type and CSPalpha knockout mouse models, as well...
- The National Institute on Aging (NIA), through the Aging Research Federal Grant Program (CFDA 93.866), awarded Rockefeller University a $196,460 project grant to conduct research on the structural and functional characterization of the mRNA export platform in Saccharomyces cerevisiae. The goal of this 18-month project is to understand the molecular determinants of mRNA export platform assembly and elucidate the mechanisms by which aging-associated mutations affect platform assembly and lead to...
- This $522,167 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research into the "Mechanisms of rDNA Instability During Aging" at the University of Virginia. The project will investigate the role of the FOB1 protein and the RNA Polymerase I transcription factor UAF in regulating double-strand breaks and recombination at the ribosomal DNA locus, a key driver of genomic instability and aging. The research will utilize innovative techniques...
- The National Institute on Aging (CFDA 93.866 Aging Research) awarded a $506,000 Project Grant to the Scripps Research Institute to engineer a novel biomolecular condensate (BMC)-based tool with tunable physicochemical properties. The goal is to create an orthogonal selective autophagy receptor (SAR)-like BMC capable of supporting autophagosome biogenesis and selective cargo recruitment. This will enable detailed investigation of the biophysical regulatory mechanisms of BMCs in autophagy, which...
- This federal Project Grant award of $291,913 was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to Virscio, Inc., a for-profit research company located in Connecticut. The award is focused on developing epigenetic and senescent biomarkers using non-human primate tissues to advance the understanding of biological aging processes and potential anti-aging strategies. The project aims to create minimally invasive biomarker tools, such as blood and skin-based assays,...
The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $478,624 Project Grant to President and Fellows of Harvard College (Harvard Medical School) to develop cross-platform fluorescent reporters for measuring the activities of the 26S proteasome and VCP/p97 complexes. These master regulators broadly control ubiquitin-dependent protein breakdown, which is closely associated with aging and age-related pathologies such as Alzheimer's disease and related dementias. The project aims to create effective probes to study the actual capacity of the proteasome system and VCP activity in aging and disease-relevant biological samples, addressing limitations of previous approaches. This research is intended to advance scientific understanding of the protein degradation system's role in the aging process and age-related neurodegenerative diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $478.6k | 8/6/25 |