Project Grant R21AG085062
- This $3,145,300 federal Project Grant award was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to investigate how the ubiquitin-proteasome system (UPS), specifically the proteasome complexes, are affected in Alzheimer's disease (AD), progressive supranuclear palsy (PSP), and Parkinson's disease. The research aims to elucidate the regulation of the proteasome complex, a key component of protein homeostasis, and its potential role in the pathogenesis of...
- The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $478,624 Project Grant to President and Fellows of Harvard College (Harvard Medical School) to develop cross-platform fluorescent reporters for measuring the activities of the 26S proteasome and VCP/p97 complexes. These master regulators broadly control ubiquitin-dependent protein breakdown, which is closely associated with aging and age-related pathologies such as Alzheimer's disease...
- This federal Project Grant award of $2,631,670 from the National Institute on Aging (CFDA 93.866 Aging Research) supports a research initiative at The Washington University to investigate age-related deficits in episodic memory. The project aims to determine how aging distinctly affects the content and structure of memory representations, and how this relates to dysfunction in different brain networks based on susceptibility to Alzheimer's disease pathology. The research will utilize plasma...
- This $147,486 Project Grant awarded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) supports research to investigate the role of chaperone-mediated autophagy (CMA) in cellular senescence and its contribution to aging. The research aims to understand: 1) if CMA activity changes upon induction of senescence, 2) if CMA modulates senescence kinetics and by what mechanism(s), 3) if CMA is required for senescent cell clearance, and 4) if restoring CMA activity...
- This $784,596 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Northeastern University supports comprehensive proteogenomic profiling of aberrant and mis-processed proteins in Alzheimer's disease and tauopathy models. The project aims to develop a proteogenomic pipeline to globally characterize disease-associated proteins with amino acid substitutions, alternative isoforms, post-translational modifications, and proteolytic cleavages across multiple brain...
- This Project Grant award of $437,875 from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund a 2-year research project at the University of California, San Diego to quantify neurovascular protein lifetimes in the central nervous system under healthy, aging, and Alzheimer's disease conditions. The key objectives are to generate a comprehensive atlas of neurovascular protein lifetimes and identify changes associated with aging and Alzheimer's disease. The project will...
- The National Institute on Aging (NIA), through its Aging Research federal grant program (CFDA 93.866), awarded a $636,342 Project Grant to Trustees of Boston University (doing business as Boston University Medical Campus) to conduct research on normal and pathological brain aging. The grant, with a performance period from August 1, 2025 to April 30, 2030, will support a multiscale modeling and empirical study of progressive myelin dystrophy, loss of synapses, and neuronal hyperexcitability in...
- This $6,925,230 Project Grant award from the National Institutes of Health (NIH) National Institute on Aging (CFDA 93.866 - Aging Research) will support a research project at The Trustees of Columbia University in the City of New York to develop a "Multi-Organ Chart of Personalized Susceptibility to Alzheimer's Disease and Aging." The overarching goal is to use large-scale multi-omics, multi-organ biomedical data, advanced artificial intelligence/machine learning, and computational...
- This $522,167 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research into the "Mechanisms of rDNA Instability During Aging" at the University of Virginia. The project will investigate the role of the FOB1 protein and the RNA Polymerase I transcription factor UAF in regulating double-strand breaks and recombination at the ribosomal DNA locus, a key driver of genomic instability and aging. The research will utilize innovative techniques...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $159,492 to Weill Medical College of Cornell University to support research focused on identifying and characterizing clonal expansions in aging and aging-related diseases. The key products/services to be delivered under this award include: Developing tools to enable the identification of candidate somatic variants at scale from publicly available data using machine learning approaches. Applying...
This $412,751 Project Grant, awarded on August 15, 2024 by the National Institute on Aging (CFDA 93.866 - Aging Research), will fund research by The Trustees of Columbia University in the City of New York to study protein turnover alterations in the aging brain. The project aims to: (I) study the stoichiometry of the ribosome and proteasome; (II) measure changes in protein complex composition; (III) reveal how aging affects protein interaction state turnover; and (IV) address the effects of age-dependent protein aggregation. This research seeks to advance the understanding of the link between brain aging, proteostasis impairment, and the preferential alteration of protein turnover associated with neurodegeneration. The goal is to provide new insights that may lead to interventions to counteract the decline of the proteome during aging.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 10/18/24 | ||
| Not listed | $412.8k | 8/7/24 |