This $1,031,595 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The awardee, Dana-Farber Cancer Institute, will define the landscape and mechanisms of protein redox regulation during aging. Specifically, the Institute will systematically map cysteine oxidation networks in mouse tissues to determine their role in coordinating protein complex assemblies relevant to age-related...
This Project Grant awarded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) provides $1,244,902 in funding to President and Fellows of Harvard College, Harvard T.H. Chan School of Public Health to conduct the "Lifestyle Factors and Longevity (LIFELONG) Study". The study aims to assess the role of dietary and other modifiable factors, such as coffee, alcohol, ultra-processed foods, dietary fiber, and adherence to healthy dietary patterns, in...
This federal Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), will support research by Tufts University School of Medicine to develop metabolomics clocks as a tool to explore the mechanisms of aging. The total funding amount is $592,507 and the award period runs from Sep 30, 2024 to Jun 30, 2029. The key objectives of the project are to: 1) develop sex- and tissue-specific metabolome clocks in the Drosophila model system that can...
This $101,925 Project Grant award was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to investigate the role of the propionate metabolism pathway in the aging process. The 2-year project aims to: Continue studying the impact of methylmalonic acid (MMA), a metabolite in the propionate pathway, on cell senescence and aging-associated pulmonary fibrosis. Characterize a novel function of propionyl-CoA (P-CoA), another pathway...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to The Johns Hopkins University provides $2,672,656.00 in funding from August 15, 2024 through April 30, 2028. The project aims to leverage genetic variation, mitochondrial DNA copy number, metabolomics, and proteomics data from large biobanks to identify novel biomarkers and causal relationships between mitochondrial function and aging-related diseases like all-cause mortality, cardiovascular disease,...
This Project Grant award of $395,796 from the National Institute on Aging's Aging Research program (CFDA 93.866) supports research at Brown University to develop genetic, pharmacological, and dietary interventions that delay the onset and progression of age-related diseases. The key objectives are to: 1) Investigate the interconnectedness and hierarchical structure of the hallmarks of aging, such as loss of genomic integrity, activation of retrotransposons, and accumulation of lipid droplets; 2)...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $158,918 to Vanderbilt University to conduct a multi-omic study exploring the impact of lifestyle variation on immunological aging patterns. The study will focus on characterizing age-associated molecular phenotypes such as gene expression, DNA methylation, and clonal hematopoiesis in peripheral blood samples collected from subsistence-level populations (Tsimane, Turkana, Orang Asli) and a...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $551,986.00 to The Jackson Laboratory to develop an explainable unified AI strategy for efficient and robust integrative analysis of multi-omics data from heterogeneous longevity studies. The goal is to identify protective genetic variants associated with exceptional human longevity, which can inform therapeutic interventions to improve human health. The 2-year project aims to: 1) create...
This federal Project Grant award for $729,567, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), will fund a study to investigate the causal impacts of two key childhood environmental conditions - school quality and infectious disease exposure - on adult health and mortality outcomes. The study aims to construct a novel dataset linking individual-level childhood environment factors to longevity, in order to examine how these modifiable conditions affect schooling,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $2,149,861 to the Albert Einstein College of Medicine to investigate the relationship between clonal hematopoiesis (CH), aging, and exceptional longevity. The key objectives are to: Determine the prevalence and mutational spectrum of CH and its association with age-related diseases in populations with exceptional longevity, comparing centenarians, their offspring, and age/sex-matched...