Project Grant R21AG093148
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Trustees of Columbia University in the City of New York a Project Grant of $6.29 million under the Aging Research program (CFDA 93.866) for the period August 1, 2025 through July 31, 2029. This grant supports research investigating the regulation of proteasome complexes in neurodegenerative diseases, with emphasis on understanding how the ubiquitin-proteasome system (UPS) becomes dysregulated in Alzheimer's disease...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Trustees of Columbia University in the City of New York a Project Grant of $1,672,296 under the Aging Research program (CFDA 93.866) to conduct genetic mapping research on RNA modifications in the aging human brain and their relationship to Alzheimer's disease (AD). The project, spanning from September 1, 2025, through May 31, 2030, will deliver three primary research products: (1) a comprehensive atlas of...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a $2,957,210 Project Grant to The Trustees of Columbia University in the City of New York (Health Sciences Division) on September 15, 2025, for research extending through August 31, 2029, under the Aging Research program (CFDA 93.866). The project, titled "Deciphering the Role of CD44 Astrocytes in Alzheimer's Disease," delivers comprehensive biomedical research aimed at understanding the molecular...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Trustees of Columbia University in the City of New York $475,377 under the Aging Research program (CFDA 93.866) for a project period from September 5, 2025, through August 31, 2027. The award supports research to determine the functional significance of microglial FOXO3 (Forkhead Box O-3) transcription factor in Alzheimer's disease (AD) pathobiology. The project addresses a critical gap in understanding how...
- Federal Grant Award Summary The National Institute on Aging awarded Columbia University's Health Sciences Division a $6.93 million Project Grant on August 1, 2025, under the Aging Research program (CFDA 93.866) to develop a multi-organ artificial intelligence-derived endophenotype (MAE) chart for personalized Alzheimer's disease and aging research. The four-year project, extending through July 31, 2029, will integrate large-scale multi-omics and multi-organ biomedical data with advanced...
- Federal Project Grant Award Summary The Trustees of Columbia University in the City of New York received a $452,375 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) for the period January 1, 2026 through December 31, 2027. This award supports biomedical research directed toward understanding the role of semaphorin 3A (SEMA3A) in microglial activation and Alzheimer's disease (AD) pathobiology. The research project will generate scientific...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Trustees of Columbia University in the City of New York a Project Grant of $452,375 under the Aging Research program (CFDA 93.866) for the period January 1, 2026 through December 31, 2027. This research project investigates the mechanisms underlying Lewy Body Dementia (LBD), the second most common form of dementia affecting over 1.4 million Americans, with a focus on astrocyte-mediated tonic inhibition in a mouse...
- Federal Grant Award Summary The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded a $3.64 million Project Grant to The Trustees of Columbia University in the City of New York on August 5, 2025, for research extending through July 31, 2030. The FUNGEN-XQTL project will generate comprehensive multi-ancestry molecular quantitative trait loci (xQTL) data and advanced computational analysis to identify causal genes, cell types, and molecular mechanisms...
- Federal Project Grant Award Summary Harvard Medical School received a $251,802 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded August 15, 2025, with completion targeted for May 31, 2027. This award supports research investigating cell-type-specific dysregulation and genetic control of alternative polyadenylation (APA) in neurodegenerative diseases, specifically Alzheimer's disease and Parkinson's disease. The research will leverage...
- Federal Grant Award Summary The National Institute on Aging awarded Columbia University's Health Sciences Division a $3.21 million Project Grant (CFDA 93.866, Aging Research program) effective August 11, 2025, through July 31, 2029, to conduct research characterizing antigen-specific immune responses in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The research will employ an unbiased, multidisciplinary approach to identify self- and non-self peptides and antigens...
The National Institute on Aging (NIA) awarded Columbia University's Health Sciences Division a Project Grant of $452,375 under the Aging Research program (CFDA 93.866) on June 15, 2026, for research on gene therapy targeting non-motor defects in synucleinopathy. The award supports translational research investigating therapeutic interventions for alpha-synuclein (α-syn) pathology, with particular focus on gastrointestinal manifestations of Parkinson's disease and related synucleinopathies. The research will develop and evaluate single-chain variable fragments (scFvs)—small antibody derivatives—delivered via self-complementary adeno-associated viral (scAAV) vectors as a gene therapy approach to inhibit α-syn oligomer and protofibril formation and promote pathological protein clearance. The project will be conducted at Columbia University's location in New York, NY, with a completion date of May 31, 2028. This funding supports the institution's translational research capabilities in neurodegenerative disease treatment, leveraging Columbia's extensive expertise in biomedical research and clinical investigation to advance understanding of disease mechanisms and develop innovative therapeutic strategies for aging-related conditions, consistent with the NIA's mission to identify prevention and treatment approaches for Alzheimer's disease and related dementias.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $452.4k | 6/5/26 |