Project Grant R21AG091800
- This federal Project Grant award of $509,413.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to conduct research on the role of epitranscriptomic regulation of microglial cells in the development and progression of Alzheimer's disease (AD). The project will investigate how methylation of adenosine residues in mRNA (m6A modification) and its regulatory proteins are altered in the brains of AD patients, and how these changes impact microglial function and the brain's...
- This Project Grant award, valued at $475,377.00, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to The Trustees of Columbia University in the City of New York. The grant aims to determine the functional significance of microglial FOXO3, a key transcription factor, in Alzheimer's disease (AD) pathobiology. The research will investigate the role of FOXO3 in regulating lipid droplet accumulation and interferon-I pathway...
- This $745,765 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Icahn School of Medicine at Mount Sinai (ISMMS) in New York aims to investigate the effects of Alzheimer's disease (AD) risk genes and aging on human microglia activity and lipid metabolism. The key focus is on understanding how genetic variants associated with increased AD risk or longevity may impact microglia's ability to clear cholesterol/lipid-rich cellular debris, a critical...
- This federal Project Grant award of $716,579, awarded by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research to investigate the role of microglia, the immune cells of the brain, in the progression of Alzheimer's disease (AD). Specifically, the research aims to genetically dissect the relationships between different activated states of microglia and their involvement in complement-mediated synapse loss, which is a key neurobiological driver of cognitive decline in...
- This $2,957,210 Project Grant was awarded by the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), to The Trustees of Columbia University in the City of New York (Health Sciences Division) on September 15, 2025. The grant supports a comprehensive research project titled "Deciphering the Role of CD44 Astrocytes in Alzheimer's Disease." The overarching objective is to elucidate the functional role of the CD44 protein in astrocytes and its...
- This Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) provides $871,419 to the University of Washington to conduct research on the role of microglia, the brain's immune cells, in the pathogenesis of Alzheimer's disease. The research aims to characterize molecular profiles and spatial organization of microglia across the adult age spectrum, both with and without Alzheimer's disease, through single-nucleus RNA sequencing of over 5,000...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to gain a mechanistic understanding of the role of cellular senescence in the pathogenesis of Alzheimer's disease (AD). The $460,625 grant will fund research at the University of Massachusetts Medical School to dissect the separate P53/P21 and P16 senescence pathways and their functional consequences in AD using human induced pluripotent stem cell-based models. The 2-year project will produce...
- The Icahn School of Medicine at Mount Sinai received a $839,933 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to conduct research on the role of N6-methyladenosine (m6A) RNA modifications in microglial dysfunction and Alzheimer's disease pathogenesis. The project aims to systematically map m6A RNA modification landscapes in microglia isolated from human brain tissue and human induced pluripotent stem cell-derived microglial models. Additionally, the...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $433,125 will fund a study to investigate the relationship between microglia, neurons, and tau pathology in Alzheimer's disease. The research will utilize a novel model system of microglial co-cultures with hippocampal assembloids derived from patient-derived induced pluripotent stem cell (iPSC) lines with MAPT mutations and healthy controls. The goal is to explore how bidirectional changes...
- This $3,030,409 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a 4-year research project led by the University of Arizona. The project aims to optimize semantic memory measures as potential early biomarkers for Alzheimer's disease pathology among older adults without dementia. The research team will investigate the sensitivity of novel semantic memory tasks to plasma biomarkers of amyloid/tau and hippocampal/medial temporal lobe atrophy,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to The Trustees of Columbia University in the City of New York, Health Sciences Division, is focused on determining the functional role and mechanistic basis for Semaphorin 3A (SEMA3A)-mediated regulation of microglial activation in Alzheimer's disease (AD). The $452,375 award, with a project period from January 1, 2026 to December 31, 2027, aims to build on the grantee's preliminary findings that SEMA3A strongly promotes beta-amyloid uptake by microglia and induces a gene expression profile resembling disease-associated microglia. The successful completion of this research is expected to unveil a previously unexplored connection between SEMA3A signaling in microglia and AD pathobiology, and lay the foundation for therapeutic strategies to modulate microglial activities in AD.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $452.4k | 12/24/25 |