Project Grant R21AG092247
- The National Institute on Aging (NIA), through its Aging Research program (CFDA 93.866), has awarded a $534,644.00 Project Grant to Temple University - Of The Commonwealth System Of Higher Education. The grant aims to characterize how the HIV-1 virus decreases neuronal clearance, leading to the progression of HIV-associated neurocognitive disorders like motor dysfunction. Key research activities include determining the post-translational regulation of the SNAPIN protein and its impact on...
- This Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) provides $1,550,462 to support a 5-year cross-sectional, longitudinal, and observational study investigating the impact of Alzheimer's disease (AD) risk genes, with a focus on APOE E4, on brain function in older Black/African American individuals living with HIV. The project aims to enroll 120 participants with HIV (60 with and 60 without the APOE E4 allele) and 80 demographically...
- This Project Grant award of $437,250.00 from the National Institutes of Health (NIH) under the Trans-NIH Research Support (CFDA 93.310) program supports research to investigate the roles of specific CD4 T cell subsets, namely T helper 1 (Th1) cells and T central memory (TCM) cells, in driving neuroinflammation associated with HIV. The research aims to assess the impact of blocking the infiltration of these CD4 T cell subsets into the central nervous system (CNS) to reduce viral loads and...
- This Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), supports research to investigate the relationship between HIV infection, aging, and cognitive decline. The $629,712 award to SRI International aims to leverage magnetic resonance imaging (MRI) and biomarker analysis to better understand how the brain's waste clearance system, known as the glymphatic system, may contribute to heightened risk of cognitive impairment in aging...
- This Project Grant award, valued at $184,506.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award supports research to investigate the dual role of amyloid beta (Aβ) in the neuropathogenesis of HIV-associated neurocognitive disorder (HAND). Specifically, the project aims to explore how Aβ influences HIV entry into the central...
- This federal Project Grant award of $601,307 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research to elucidate the mechanism by which HIV-1 downregulates specific RNA modifications (YW, DPH, and M1ACP3Ps) that normally repress ribosomal frameshifting on HIV-1 mRNA. The research aims to determine how this deregulation of RNA...
- The U.S. Department of Health and Human Services, National Institutes of Health (NIH) awarded a $768,131 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the University of California, San Diego (UCSD) to investigate the role of the triggering receptor expressed on myeloid cells (TREM) 2 in Alzheimer's disease pathogenesis in people with HIV (PWH). The 5-year project aims to study how HIV infection and related inflammatory stimuli can alter TREM2 levels in...
- This $788,121 Project Grant awarded by the National Institute on Aging (CFDA 93.866 Aging Research) will fund a 5-year cross-sectional, longitudinal, and observational study to investigate the impact of Alzheimer's disease (AD) risk genes, with a focus on APOE E4, on brain function in HIV-positive older Black/African American adults. The study aims to increase understanding of Alzheimer's disease and related dementias (ADRD) risk factors in this vulnerable population, who face an increased...
- This $418,625 Project Grant awarded by the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) to Drexel University supports research to develop a novel approach using RNA interference (RNAi) to silence HIV transcription in myeloid cells. The goal is to functionally eliminate the HIV reservoir in the central nervous system by inducing a stable heterochromatic state to block proviral transcription and production of new virions in chronically infected...
- This federal Project Grant award, totaling $745,822.00 and provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to investigate the role of the PERK kinase in HIV-induced neuroinflammation and neurocognitive impairment (NCI) in people with HIV (PWH). The University of Pennsylvania, as the primary grantee, will use biochemical, cellular, and pharmacologic approaches to assess PERK's potential as a predictive...
This federal Project Grant award from the Department of Health and Human Services National Institutes of Health (CFDA 93.310 - Trans-NIH Research Support) provides $435,875 to Temple University to investigate the role of app-related circular RNAs (circRNAs) induced by HIV-1 infection in the formation of beta-amyloid, a key hallmark of Alzheimer's disease. The research aims to understand the causal link between HIV-1 infection and the development of HIV-associated neurocognitive disorders, which share molecular characteristics with Alzheimer's disease. The project will analyze how HIV-1 influences the expression of specific circRNAs, such as circ_0007556 and circ_0004381, that may contribute to beta-amyloid accumulation. The award period runs from August 2025 to July 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $435.9k | 8/6/25 |