Project Grant R56AG089864

Award Date 9/30/24
Completion Date 9/29/25
Dollars Obligated $1.6M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Washington, DC 20057, USA
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This $407,000 Project Grant from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research by the University of Texas Rio Grande Valley (UTRGV) to investigate the relationship between HIV infection and the onset and progression of Alzheimer's disease (AD) using AD mouse models infected with a chimeric HIV strain. The central hypothesis is that HIV may accelerate the development of cognitive decline in AD. The 2-year study will conduct longitudinal behavioral,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $660,875 to the University of Washington to investigate the protective effect of African-derived APOE alleles on Alzheimer's disease (AD) risk, including their impact on lipid and inflammatory traits. The key objectives are to: 1) Determine which variants on African-derived and European-derived APOE haplotypes may explain the association between African-derived APOE alleles and reduced AD...
This Cooperative Agreement award from the National Institute on Aging (NIA), part of the National Institutes of Health, under the Aging Research Federal Grant Program (CFDA 93.866), will provide $8,101,854 to the University of Miami to increase diversity in the Alzheimer's Disease Sequencing Project (ADSP). The project aims to generate whole genome sequencing, Alzheimer's disease plasma biomarkers, and cardiovascular disease biomarkers for approximately 9,000 individuals of African ancestry,...
This $124,526 Project Grant was awarded by the National Institute on Aging (NIA) under CFDA 93.866 - Aging Research. The grant will support a research project at the University of Florida to examine disparities in the risk of dementia among people living with HIV (PWH) aged 50 and older. The project will leverage real-world data sources, including electronic health records and claims data, linked with social determinants of health data, to develop machine learning-based prediction models for...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $431,750 to Arizona State University (ASU) to investigate the mechanisms by which a specific genetic variant in the apolipoprotein E (APOE) gene, APOE R145C, increases the risk of Alzheimer's disease (AD) among individuals of African ancestry. The research will utilize ASU's expertise in stem cell bioengineering, neurodegenerative disease modeling, and genome editing to generate human...
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This $4,950,026 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The Icahn School of Medicine at Mount Sinai is investigating potential synergy between HIV infection and amyloid beta, a hallmark of Alzheimer's disease, in promoting memory impairment. Researchers will characterize enhanced HIV neuropathogenesis in familial and late-onset Alzheimer's disease mouse models...
This $1,505,109 Project Grant awarded by the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), aims to identify undiagnosed Alzheimer's disease (AD) in non-Hispanic White, Hispanic/Latino, and non-Hispanic African American populations. The project will leverage electronic health records and genetic data to develop disease trajectory models and polygenic risk scores to detect undiagnosed AD, while addressing the issue of underdiagnosis in underserved...
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