This $407,000 Project Grant from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research by the University of Texas Rio Grande Valley (UTRGV) to investigate the relationship between HIV infection and the onset and progression of Alzheimer's disease (AD) using AD mouse models infected with a chimeric HIV strain. The central hypothesis is that HIV may accelerate the development of cognitive decline in AD. The 2-year study will conduct longitudinal behavioral,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $660,875 to the University of Washington to investigate the protective effect of African-derived APOE alleles on Alzheimer's disease (AD) risk, including their impact on lipid and inflammatory traits. The key objectives are to: 1) Determine which variants on African-derived and European-derived APOE haplotypes may explain the association between African-derived APOE alleles and reduced AD...
This Cooperative Agreement award from the National Institute on Aging (NIA), part of the National Institutes of Health, under the Aging Research Federal Grant Program (CFDA 93.866), will provide $8,101,854 to the University of Miami to increase diversity in the Alzheimer's Disease Sequencing Project (ADSP). The project aims to generate whole genome sequencing, Alzheimer's disease plasma biomarkers, and cardiovascular disease biomarkers for approximately 9,000 individuals of African ancestry,...
This $124,526 Project Grant was awarded by the National Institute on Aging (NIA) under CFDA 93.866 - Aging Research. The grant will support a research project at the University of Florida to examine disparities in the risk of dementia among people living with HIV (PWH) aged 50 and older. The project will leverage real-world data sources, including electronic health records and claims data, linked with social determinants of health data, to develop machine learning-based prediction models for...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $431,750 to Arizona State University (ASU) to investigate the mechanisms by which a specific genetic variant in the apolipoprotein E (APOE) gene, APOE R145C, increases the risk of Alzheimer's disease (AD) among individuals of African ancestry. The research will utilize ASU's expertise in stem cell bioengineering, neurodegenerative disease modeling, and genome editing to generate human...
This Project Grant award, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), supports a comprehensive study to determine the prevalence and clinical characteristics of mild cognitive impairment (MCI) and Alzheimer's-related dementia (ADRD) among older adults living with HIV in Uganda. The $1,103,953 award, which began on Sep 15, 2024 and runs through Aug 31, 2025, will fund the following key activities: Comprehensive neuropsychological assessments among 600 older...
This $4,950,026 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The Icahn School of Medicine at Mount Sinai is investigating potential synergy between HIV infection and amyloid beta, a hallmark of Alzheimer's disease, in promoting memory impairment. Researchers will characterize enhanced HIV neuropathogenesis in familial and late-onset Alzheimer's disease mouse models...
This $1,505,109 Project Grant awarded by the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), aims to identify undiagnosed Alzheimer's disease (AD) in non-Hispanic White, Hispanic/Latino, and non-Hispanic African American populations. The project will leverage electronic health records and genetic data to develop disease trajectory models and polygenic risk scores to detect undiagnosed AD, while addressing the issue of underdiagnosis in underserved...
This $5,274,018 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The J. David Gladstone Institutes will study the susceptibility and resistance to the detrimental effects of the Apolipoprotein E4 (APOE4) genetic risk factor for Alzheimer's disease. The research aims to characterize neurophysiological, behavioral, and neuropathological differences between new APOE4 mouse lines...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $445,500 to the University of Cincinnati to investigate how the sickle cell trait (SCT) and the apolipoprotein E4 (APOE E4) risk allele interact to impact brain structure, lipidomics, neuroinflammation, and cognitive deficits among older African Americans. The 2-year project aims to elucidate the mechanisms by which SCT modifies the effects of APOE E4 on Alzheimer's disease and related dementias...