Project Grant R21AG094321
- This $823,691 Project Grant award was provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) to investigate the role of immune checkpoints in the central nervous system (CNS) of people living with HIV (PLWH) and their association with HIV-associated neurocognitive disorder (HAND). The research aims to determine the profiles and biological functions of soluble immune checkpoints (sICPs) in the CNS of PLWH and a simian immunodeficiency...
- This Project Grant award, valued at $184,506.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award supports research to investigate the dual role of amyloid beta (Aβ) in the neuropathogenesis of HIV-associated neurocognitive disorder (HAND). Specifically, the project aims to explore how Aβ influences HIV entry into the central...
- This federal Project Grant award of $601,307 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research to elucidate the mechanism by which HIV-1 downregulates specific RNA modifications (YW, DPH, and M1ACP3Ps) that normally repress ribosomal frameshifting on HIV-1 mRNA. The research aims to determine how this deregulation of RNA...
- This federal Project Grant award of $194,375.00, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), aims to determine the impact of persistent HIV in the central nervous system (CNS) on inflammation, brain structure and function, and cognition in people living with HIV. The primary goals are to: 1) Evaluate the specific contribution of HIV in the CNS to...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $698,390 to the Regents of the University of California at Riverside to conduct research aimed at harnessing innate immunity to control the neuroinflammatory HIV reservoir. The key objectives are to investigate how HIV infection triggers an interferon (IFN) response, how HIV...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,025,015 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Scintillon Institute in California. The grant, awarded on August 11, 2025, supports the development of a next-generation preclinical model of NeuroHIV that better recapitulates the neuro-immune-vascular system interactions in the context of antiretroviral therapy-mediated HIV suppression....
- This federal Project Grant award, worth $382,072, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award aims to investigate the epigenetic mechanisms underlying HIV-associated neurocognitive disorders (HAND), which remain a significant complication of HIV infection despite antiretroviral therapy. The research will focus on characterizing the...
- This federal Project Grant award, totaling $745,822.00 and provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to investigate the role of the PERK kinase in HIV-induced neuroinflammation and neurocognitive impairment (NCI) in people with HIV (PWH). The University of Pennsylvania, as the primary grantee, will use biochemical, cellular, and pharmacologic approaches to assess PERK's potential as a predictive...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will provide $880,000 to Old Dominion University from September 2024 through August 2026. The project aims to investigate the therapeutic effects of microglia depletion and repopulation (MGDR) on mitigating hand and neuropsychiatric symptoms in the context of chronic HIV infection. Specifically, the research will explore the impact of MGDR on brain pathology in HIV-infected mouse models, examining its...
- This $104,602 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program supports research at Drexel University to investigate how dopamine signaling in macrophages drives inflammation and impacts the progression of HIV infection. The research aims to elucidate the alternative dopamine signaling pathways in immune cells and how they are exacerbated by HIV, with the goal of informing new...
This Project Grant award of $437,250.00 from the National Institutes of Health (NIH) under the Trans-NIH Research Support (CFDA 93.310) program supports research to investigate the roles of specific CD4 T cell subsets, namely T helper 1 (Th1) cells and T central memory (TCM) cells, in driving neuroinflammation associated with HIV. The research aims to assess the impact of blocking the infiltration of these CD4 T cell subsets into the central nervous system (CNS) to reduce viral loads and neuroinflammation in a relevant rhesus macaque model of HIV. Through comprehensive virological and immunological analyses of distinct brain regions and border tissues, the study seeks to provide insights into how these CD4 T cell subsets contribute to HIV-associated neurocognitive disorders (HAND). The award period runs from August 15, 2025 to July 31, 2027 and will be performed by the University of Pittsburgh.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $437.3k | 8/7/25 |