Project Grant R21AG091151
- Federal Project Grant Summary Albert Einstein College of Medicine received a $462,000 Project Grant award dated August 15, 2025, from the National Institute on Aging under the Aging Research program (CFDA 93.866) to conduct research on thymus function regulation and age-related decline. The project, scheduled for completion by July 31, 2027, will deliver comprehensive scientific research outputs investigating the role of the sympathetic nervous system in thymic involution. The primary...
- The National Institute on Aging awarded Albert Einstein College of Medicine $134,044 under the Aging Research program (CFDA 93.866) on July 1, 2026, to establish a program in life-course epidemiology of Alzheimer's disease and related dementias (ADRD) with emphasis on prevention and early intervention. The award funds development of a national resource and research training program centered on understanding modifiable ADRD risk factors across the lifespan, addressing a critical gap in Einstein's...
- The National Institute on Aging awarded Albany Medical College $246,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate inter-organelle dynamics during aging in eukaryotic cells. The work will characterize spatial contexts of inter-organelle communication using C. elegans as a model system to identify organellar signatures that develop during aging and proteostasis decline, establishing a platform to understand how aging impacts organelle interactions and...
- Albert Einstein College of Medicine will conduct biomedical research to investigate the relationship between surgical stress, physiologic resilience, and aging hallmarks, with particular focus on sex-dependent vulnerabilities. Funded by the National Institute on Aging under the Aging Research program (CFDA 93.866), this $699,344 Project Grant award (September 1, 2025 – August 31, 2027) supports research establishing the spatial, temporal, and sex-dependent impact of surgical stress on aging...
- The National Institute on Aging awarded New York University $708,137 on February 1, 2026, under the Aging Research program (CFDA 93.866) to develop and validate technologies for probing the biophysical properties of aging cells. The funded work centers on developing genetically encoded multimeric particles (GEMs) as high-throughput microrheology probes to measure the physical properties of cell interiors—particularly within organelles including the nucleus, cytoplasm, endoplasmic reticulum,...
- The National Institute on Aging awarded Icahn School of Medicine at Mount Sinai $230,388 on March 4, 2026, under the Aging Research program (CFDA 93.866) to dissect the role of the PICALM/EED locus on myeloid cells in Alzheimer's disease. The recipient will conduct research to understand how an Alzheimer's disease risk enhancer on chromosome 11 influences expression of two target genes—PICALM (phosphatidylinositol binding clathrin assembly protein) and EED (embryonic ectoderm development)—and to...
- The National Institute on Aging awarded Weill Medical College of Cornell University $362,342 on March 17, 2026, under the Aging Research program (CFDA 93.866) to conduct research on lysosome homeostasis in aging-related diseases. The research investigates how lysosomes maintain cellular health through homeostatic mechanisms that sense lysosomal stress and either repair damaged lysosomes or generate new ones via transcriptional activation. The study focuses on a mechanism called conjugation of...
- The National Institute of General Medical Sciences awarded Albert Einstein College of Medicine $420,000 on September 1, 2026, to investigate the molecular mechanisms controlling a diapause-like dormant cell state under CFDA 93.859 (Biomedical Research and Research Training), assistance type Project Grant R35GM163637. The research characterizes how somatic cells adopt a reversible, quiescence state resembling embryonic diapause in response to cellular stress and damage. Work addresses three...
- The National Institute on Aging awarded New York University $466,125 under the Aging Research program (CFDA 93.866) on January 15, 2026, to develop innovative magnetic resonance imaging analysis tools for identifying microstructural biomarkers of skeletal muscle health across the lifespan. The project, titled "(Micro)structural Biomarkers of Skeletal Muscle Health Across the Lifespan," addresses sarcopenia—a leading cause of disability and mortality in aging populations—by creating...
- The National Institute on Aging awarded Icahn School of Medicine at Mount Sinai $704,145 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop and apply computational methods for inferring the natural history of Alzheimer's disease from sparse longitudinal molecular and neuroimaging data. The recipient will develop an innovative approach that leverages temporal signal in sparse longitudinal datasets to reconstruct the timeline of Alzheimer's disease progression and...
The National Institute on Aging awarded Albert Einstein College of Medicine $462,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate chaperone-mediated autophagy in aging-associated cardiovascular fibrosis. The research examines the role of declining chaperone-mediated autophagy (CMA) activity in fibroblasts as a driver of progressive fibrotic remodeling in aging hearts and vessels. The study will test whether age-related CMA decline in cardiac fibroblasts mediates fibrosis development and contributes to diastolic dysfunction and heart failure. Three specific aims structure the work: documenting the time course of fibroblast CMA decline in aging hearts and vessels using CMA reporter mice, examining the effects of fibroblast-specific CMA disruption on age-associated cardiovascular fibrosis and dysfunction, and investigating whether fibroblast-specific CMA activation delays fibrotic cardiac and vascular remodeling. The research employs genetically modified mice with fibroblast-specific disruption of LAMP2A, a critical lysosomal membrane protein involved in CMA substrate binding and internalization. Performance of work occurs in Bronx, New York. The period of performance runs from September 1, 2026, through August 31, 2028. Albert Einstein College of Medicine is a private tax-exempt educational institution and serves as the prime recipient under this project grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $462.0k | 8/31/26 |