This $383,750 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will support research by the University of Nebraska Medical Center (UNMC) to explore the molecular, neuro-immune and behavioral changes that occur during HIV-associated progressive aging using a long-term humanized mouse model. The goal is to determine how HIV latency and antiretroviral therapy (ART) contribute to premature aging, referred to as "LAAGING", and the associated...
This $407,000 Project Grant from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research by the University of Texas Rio Grande Valley (UTRGV) to investigate the relationship between HIV infection and the onset and progression of Alzheimer's disease (AD) using AD mouse models infected with a chimeric HIV strain. The central hypothesis is that HIV may accelerate the development of cognitive decline in AD. The 2-year study will conduct longitudinal behavioral,...
The National Institute on Aging (NIA), through its Aging Research program (CFDA 93.866), has awarded a $534,644.00 Project Grant to Temple University - Of The Commonwealth System Of Higher Education. The grant aims to characterize how the HIV-1 virus decreases neuronal clearance, leading to the progression of HIV-associated neurocognitive disorders like motor dysfunction. Key research activities include determining the post-translational regulation of the SNAPIN protein and its impact on...
This Project Grant award of $222,000.00 from the National Institute on Aging (NIA), under the Aging Research (CFDA 93.866) federal grant program, will fund research to investigate whether increasing autophagy via inhibition of the Beclin1-Bcl2 complex can delay age-related phenotypes and improve cognitive decline associated with HIV infection in adult and old mice. The research will be conducted by Florida International University (FIU) from September 30, 2024 to July 31, 2026. The key...
This $1,454,724 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to understand the mechanisms involved in HIV-1 latency in the central nervous system (CNS). The primary objectives are to identify key factors, pathways, and regulators that determine the establishment, maintenance, and reactivation of latent HIV-1 virus in brain myeloid cell lineages, such as microglia and macrophages. The research will...
This Project Grant award of $263,844 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) aims to track inflammatory macrophage states in mouse models and cerebrospinal fluid of HIV-suppressed individuals to classify neuroinflammation and identify molecular markers associated with cognitive deficits. The project has two key objectives: 1) Determine the spatial distribution of microglia activation states in inflammatory mouse models for aging and HIV...
This Project Grant award, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), supports a comprehensive study to determine the prevalence and clinical characteristics of mild cognitive impairment (MCI) and Alzheimer's-related dementia (ADRD) among older adults living with HIV in Uganda. The $1,103,953 award, which began on Sep 15, 2024 and runs through Aug 31, 2025, will fund the following key activities: Comprehensive neuropsychological assessments among 600 older...
This Project Grant award of $678,674 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) aims to identify the molecular mechanisms triggering the activation of intracellular innate immunity in microglia and characterize the cellular crosstalk between HIV-infected and non-infected cells in the brain under physiological concentrations of combination antiretroviral therapy (cART). The research plan includes experimental studies using...
This $4,950,026 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The Icahn School of Medicine at Mount Sinai is investigating potential synergy between HIV infection and amyloid beta, a hallmark of Alzheimer's disease, in promoting memory impairment. Researchers will characterize enhanced HIV neuropathogenesis in familial and late-onset Alzheimer's disease mouse models...
This federal Project Grant award of $794,341.00, provided by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) program, is funding research to investigate the mechanistic roles of cellular senescence and blood-brain barrier dysfunction in mediating pathogen-induced Alzheimer's disease (AD) progression. The key goals are to leverage experimental mouse models, molecular characterization of endogenous retrovirus RNA sensing, and human iPSC models to elucidate how...