The National Institute on Aging (NIA), through its Aging Research program (CFDA 93.866), has awarded a $534,644.00 Project Grant to Temple University - Of The Commonwealth System Of Higher Education. The grant aims to characterize how the HIV-1 virus decreases neuronal clearance, leading to the progression of HIV-associated neurocognitive disorders like motor dysfunction. Key research activities include determining the post-translational regulation of the SNAPIN protein and its impact on...
This $383,750 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will support research by the University of Nebraska Medical Center (UNMC) to explore the molecular, neuro-immune and behavioral changes that occur during HIV-associated progressive aging using a long-term humanized mouse model. The goal is to determine how HIV latency and antiretroviral therapy (ART) contribute to premature aging, referred to as "LAAGING", and the associated...
This $407,000 Project Grant from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research by the University of Texas Rio Grande Valley (UTRGV) to investigate the relationship between HIV infection and the onset and progression of Alzheimer's disease (AD) using AD mouse models infected with a chimeric HIV strain. The central hypothesis is that HIV may accelerate the development of cognitive decline in AD. The 2-year study will conduct longitudinal behavioral,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will provide $880,000 to Old Dominion University from September 2024 through August 2026. The project aims to investigate the therapeutic effects of microglia depletion and repopulation (MGDR) on mitigating hand and neuropsychiatric symptoms in the context of chronic HIV infection. Specifically, the research will explore the impact of MGDR on brain pathology in HIV-infected mouse models, examining its...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $479,375 to Florida International University to conduct research on the effect of a small molecule activator of autophagy, TPI-132, on insulin signaling, senescence, and neuropathology in mouse models of Alzheimer's disease. The goal is to optimize TPI-132 to increase its potency, brain penetration, and reduce toxicity, and then evaluate its impacts on neuronal senescence, synapses, protein...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $1,161,154 to the University of South Carolina to conduct research aimed at addressing HIV-1-associated neurocognitive disorders (HAND) in older adults. The key objectives are to: 1) Develop "dendritic spine-targeted" therapeutics, such as the isoflavandiol estrogen S-equol and a specific estrogen B-receptor agonist, to restore synaptodendritic integrity and mitigate neurocognitive...
This $4,950,026 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The Icahn School of Medicine at Mount Sinai is investigating potential synergy between HIV infection and amyloid beta, a hallmark of Alzheimer's disease, in promoting memory impairment. Researchers will characterize enhanced HIV neuropathogenesis in familial and late-onset Alzheimer's disease mouse models...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate how aging produces ultrastructural alterations to neuronal autophagy, which is critical for maintaining neuronal homeostasis and function. The $429,000 award to the University of Texas Health Science Center at Houston will be used to accomplish two specific aims over the 2-year project period starting January 1, 2025: Compare the ultrastructural features of axonal autophagic...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $1,055,313 in funding to the University of Miami to conduct research on the role of glial cells in the aging process. Specifically, the researchers will leverage C. elegans genetics and advanced imaging and supplementation methods to investigate how the glial ion channel CLH-1 controls organismal aging. The key objectives are to establish the function of glial CLH-1 in influencing aging and to...
This Project Grant award from the National Institute on Aging's (NIA) Aging Research program (CFDA 93.866) provides $660,402 to the University of Maryland, Baltimore (UMB) to study the role of autophagy, a cellular process that recycles damaged components, in regulating lipid metabolism and inflammation in microglia during brain aging and neurodegenerative diseases like Alzheimer's disease (AD). The research aims to determine how microglial lipid phagocytosis inhibits autophagy, leading to the...