This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $649,679 to the Regents of the University of Minnesota to conduct research on mechanisms of aging. The project aims to evaluate how a population of mouse T cells can be iteratively boosted and passaged among young mice for over 11 years, exceeding the normal mouse lifespan, while retaining functional competence and proliferative potential. The research will investigate factors such as...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $378,750 in funding to Saint Louis University to conduct research on the role of cytosolic DNA-induced sterile inflammation in driving cellular and organismal progeria/aging hallmarks. The key objectives are to: 1) define the non-canonical mode of STING stimulation upon progerin-induced accumulation of cytosolic DNA, 2) examine how STING, STAT1, and downstream interferon-stimulated genes like...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $227,250 to Saint Louis University to investigate the role of the protease cathepsin L in modulating the nuclear proteome, particularly in relation to lamin proteins involved in cellular aging and disease. The 2-year project, running from November 2024 to October 2026, aims to elucidate the mechanisms by which cathepsin L can mitigate the toxic effects of the progerin protein that causes...
This $312,900 Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) supports research to identify the genetic basis of extraordinary lifespan in a model organism, the nematode Caenorhabditis elegans. The 5-year project aims to: (1) discover the genetic variants responsible for longevity in a naturally occurring long-lived C. elegans isolate, (2) analyze how natural variation affects lifespan and develop tissue-specific "aging...
This $654,238 Project Grant award from the National Institute on Aging (NIA) under CFDA Program 93.866 - Aging Research supports research to investigate the role of senescent cells in brain aging and the development of Alzheimer's disease and related dementias (ADRD). The project aims to generate high-resolution spatial omics data from ADRD brains and mouse models to identify molecular changes in the microenvironment of senescent neurons compared to healthy neurons. The work will be conducted by...
This $679,424 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports preclinical studies to evaluate the efficacy of a novel nanoligomer treatment for reducing neuroinflammation and protecting against cognitive decline in mouse models of brain aging and Alzheimer's disease. The research aims to determine the ideal application of the NF-kB/NLRP3-targeted nanoligomer treatment, whether for prevention during aging or treatment of pathology, and to...
This federal Project Grant award of $416,625 from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), will support research at Saint Louis University (SLU) to investigate the effects of aging, sex, and hormonal status on atherosclerotic cardiovascular disease (CVD). The key objectives are to: 1) comprehensively map inflammatory cell profiles and cell-cell communication networks in atherosclerotic plaques of young and old male and female mice, including old...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $391,850 to Third Element Bio Inc. to develop RUNX1-targeting antisense oligonucleotides (ASOs) as a novel therapeutic approach to slow cognitive decline in Alzheimer's disease (AD). The key goals are to 1) optimize the safety and potency of the lead RUNX1 ASO candidate, and 2) demonstrate the efficacy of RUNX1 ASOs in a mouse model of AD using molecular biomarkers and behavioral endpoints. This...
This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at the University of Washington to investigate genomic alterations in skeletal muscle associated with aging. The key objectives are to: Explore if alternative splicing of mRNA results in quantitative differential isoform changes associated with aging, potentially leading to increased expression of non-functional proteins relevant for healthy muscle function. The researchers...
This federal Project Grant award of $802,034 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) will fund a multimodal, multiscale, and multistage systems biology (M3SB) infrastructure to advance precision medicine for Alzheimer's disease (AD) and longevity. The project aims to: 1) conduct multi-omic analyses to identify bioage-modifying targets and repurposable medicines for AD/ADRD; 2) build inflammatory aging (iAge) and phenoAge clocks using longitudinal...